Overweight and Obesity
Conditions
Keywords
Overweight, Obesity, Blood cells, Metabolic health, Weight loss
Brief summary
The aim of this study is to design and validate a test, METAHEALTH-TEST, based in gene expression analysis in blood cells, to quickly and easily analyse metabolic health. This test will be used to analyse metabolic improvement in overweight/obese individuals and in metabolically obese normal-weight (MONW) individuals after undergoing a weight loss intervention and/or an intervention for improvement in eating habits and lifestyle.
Interventions
OTHERDietary and physical activity intervention
OW-OB group: 6-month program of weight loss consisting in a low-calorie food plan (30% reduction in the individual energy requirements) with dietary sessions and exercise counselling. MONW group: 6-month program to improve eating habits (Mediterranean diet) with dietary sessions and exercise counselling.
Sponsors
University of the Balearic Islands
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Volunteers are assigned to three groups for the duration of the study: 1. Normal-weight 2. Overweight-Obese 3. Metabolically obese normal-weight
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 18-45 years * Participants with no chronic disease (excluding those related to overweight/obesity)
Exclusion criteria
* Minors or older than 45 years * Presence of a metabolic illness * Intake of regular medication or drugs * Precedents of alcohol or drug consumption * Physic of psychic disability
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of individuals responding to fasting assessed by changes in gene expression profile of blood cells | Baseline point (all groups) | The effect of fasting on gene expression profile of blood cells will be analyzed by real-time RT-qPCR and microarray |
| Weight | Baseline point (all groups) | Weight (kg) |
| Body Mass Index (BMI) | Baseline point (all groups) | Weight and height will be combined to report BMI in kg/m\^2). |
| Body composition | Baseline point (all groups) | Body composition (fat mass in kg) measured using a DXA scanner |
| Circulating glucose, triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and C-reactive protein (CRP) | Baseline point (all groups) | Circulating parameters measured in mg/dL |
| Circulating gamma-glutamyl transpeptidase (GGT) | Baseline point (all groups) | GGT measured in U/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Height | Baseline point (all groups) | Height (m) |
| Waist-hip ratio | Baseline point (all groups) | Waist-hip ratio |
| Blood pressure | Baseline point (all groups) | Blood pressure (mm Hg) |
Countries
Spain
Outcome results
None listed