Rheumatology Patient Registry and Biorepository

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04402086

Enrollment

5000

Registered

2020-05-26

Start date

2020-08-04

Completion date

2030-06-01

Last updated

2026-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult Onset Still Disease, Ankylosing Spondylitis, Antiphospholipid Syndrome, Behcet Disease, Dermatomyositis, Giant Cell Arteritis, Lyme Disease, Mixed Connective Tissue Disease, Polymyalgia Rheumatica, Polymyositis, Psoriatic Arthritis, Reactive Arthritis, Rheumatic Diseases, Rheumatoid Arthritis, Sarcoidosis, Scleroderma, Sjogren's Syndrome, Systemic Lupus Erythematosus, Systemic Sclerosis, Undifferentiated Connective Tissue Diseases

Brief summary

To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.

Detailed description

A rheumatology biorepository will be created to permit comparative analyses between the rheumatic diseases in order to increase the understanding of disease pathogenesis. Patients seen at Yale clinics diagnosed with rheumatic diseases are invited to participate in this study. These rheumatic diseases include, but are not limited to: adult onset Still's disease, ankylosing spondylitis, psoriatic arthritis, reactive arthritis, antiphospholipid syndrome, systemic lupus erythematosus, Behcet's disease, dermatomyositis, polymyositis, giant cell arteritis and other vasculitides, Lyme's disease, mixed connective tissue disease, polymyalgia rheumatica, rheumatoid arthritis, sarcoidosis, systemic sclerosis (scleroderma), Sjogren's syndrome, and undifferentiated connective tissue disease.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Yes

Inclusion criteria

for Rheumatology Patients: * Patients ≥18 years old with a diagnosis of a rheumatic autoimmune disease including, but not limited to: adult onset Still's disease, ankylosing spondylitis, antiphospholipid syndrome, Behcet's disease, dermatomyositis, giant cell arteritis, mixed connective tissue disease, polymyalgia rheumatica, polymyositis, psoriatic arthritis, reactive arthritis, rheumatoid arthritis, sarcoidosis, scleroderma, Sjogren's syndrome, systemic lupus erythematosus, undifferentiated connective tissue disease and vasculitis. * Receiving clinical care at Yale Rheumatology clinics

Exclusion criteria

for Rheumatology Patients: * Unable to provide informed consent * No patients will be excluded based on gender or ethnicity or pregnancy status. * Women who are currently pregnant will need to wait to donate a skin biopsy until after they deliver. * Patients allergic to lidocaine or epinephrine or have a history of impaired wound healing will not be able to donate a skin biopsy. Inclusion Criteria for Healthy Volunteers: * Age ≥ 18 years old * No chronic skin conditions * No diagnosis of a rheumatic autoimmune disease (e.g., lupus, rheumatoid arthritis) * Normal BMI

Design outcomes

Primary

Measure	Time frame	Description
Correlate outcomes and biomarkers of rheumatic diseases	10 years	Evaluate clinical data and biospecimens to correlate outcomes and biomarkers of rheumatic diseases.

Countries

United States

Contacts

CONTACTStephanie Perez, MS, BS

s.perez@yale.edu203-737-5571

PRINCIPAL_INVESTIGATORMonique Hinchcliff, MD

Yale University

Outcome results