COVID-19, Critical Illness
Conditions
Keywords
recovery
Brief summary
Patients who are critically ill with COVID-19 requiring life support in an intensive care unit (ICU) have increased risk of morbidity and mortality. Currently the ICU community does not know what effect the disease, the ICU admission, physiotherapy interventions and life support have on their long-term quality of life and whether they can return to their pre-illness level of function following ICU. COVID-Recovery will describe the physiotherapy interventions delivered to critically ill patients with COVID-19. In survivors, COVID-Recovery will utilise telephone follow-up of ICU survivors to assess disability-free survival and quality of life at 6 months after ICU admission. Additionally, COVID-Recovery will identify if there are predictors of disability-free survival. COVID-Recovery will aim to select up to 300 patients diagnosed with COVID-19 from ICUs in Australia. If they survive to hospital discharge, patients will be invited to receive a telephone questionnaire at 6 months after the ICU admission that aims to assess their long-term outcomes, including physical, cognitive and emotional function, quality of life, and whether they have been able to return to work following ICU discharge. To describe the experience of critical illness in survivors of COVID-19 and their family members. To explore and describe functional recovery, respiratory system function and respiratory health morbidity up to 6 months after ICU admission in persistently critically ill adults with COVID-19
Interventions
None listed
Sponsors
The Alfred
Australian and New Zealand Intensive Care Research Centre
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
17 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. COVID-19 patients who have been admitted to ICU for \> 24 hours 2. Patients aged over 17 years Persistent critical illness cohort 1. As above 2. An ICU admission of at least 10 consecutive days
Exclusion criteria
* Previous enrolment in this study in a prior ICU admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disability-free survival | 6 months | a composite measure of WHODAS 2.0 - 12 level and hospital survival |
| Physiotherapy intervention | During the ICU stay until 3 months | The physiotherapy interventions provided to patients with COVID-19 admitted to the ICU and health outcomes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive function | 6 months | Montreal Cognitive Assessment Blind |
| Anxiety and depression | 6 months | Hospital Anxiety and Depression Scale |
| Screening for post-traumatic distress | 6 months | Impact of Events Scale Revised |
| Work Status | 6 months | WHODAS 2.0 |
| Health status | 6 months | Health related quality of life measured with EQ5D-5L score from 0 to 100 |
| The reported barriers to delivering physiotherapy interventions | During the ICU stay until 28 days | Physiotherapist reported barriers to delivering the intervention |
| Adverse events during physiotherapy interventions | During the ICU stay until 28 days | Adverse events that require the intervention to be ceased for medical intervention |
| Phenomenological data of the patient and family experience | 6 months | Qualitative interviews |
| Proportion of patients with COVID-19 who received physiotherapy in ICU | During the ICU stay until 28 days | — |
| Global function | 6 months | World Health Organization Disability Assessment Schedule 2.0 12L |
Countries
Australia
Outcome results
None listed