Covid19, Sars-CoV2
Conditions
Brief summary
The objective of this study is to assess the long-term outcomes after hospital admission with Covid-19 with respect to pulmonary function, physical capacity, imaging, quality of life and socioeconomic outcomes.
Detailed description
Patients will be invited to follow-up visits 3 and 12 months after hospitalization with COVID19. Inclusion will take place during 2020. We expect to enroll 180 non-ICU patients and 36 ICU patients.
Interventions
DIAGNOSTIC_TESTImaging of the lungs
After hospital admissions with COVID19 patients will come for two clinical visits to complete a number of questionnaires, pulmonary function testing, six-minute walk test, blood sampling and imaging of the lungs.
Sponsors
University of Aarhus
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Inclusion criteria
* Infection with Sars-CoV-2
Exclusion criteria
* Unable to attend hospital visits due to frailty or severe disease * Unable to understand and complete questionnaires due to intellectual or language limitations / deficits
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Imaging of the lungs | 3 months after discharge | Expert evaluation |
| Pulmonary function tests | 3 months after discharge | Liter |
| Six-minute walk test | Performed 3 months after discharge | Walking distance (meters) and change in oxygen saturation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospital anxiety and Depression score (HADS) | 3 months after discharge | 0-21. The higher the score, the more risk of anxiety or depression. |
| Comorbidities | 12 months after discharge | Any pre-COVID-19 comorbidity and treatment with immmunosuppressants will be registered. |
| Short Form-36 (SF-36) questionnaire | 3 months after discharge | 0-100 scale. The lower the score, the more disability. |
| Biobanking of blood | 3 months after discharge | Knowledge regarding COVID19 is drastically evolving. Biobanking makes it possible to investigate blood samples in the future corresponding to ongoing evidence. |
| Blood sample at routine follow up. | 3 months after discharge | Change in outcomes between discharge and follow-up visits will be evaluated |
| Fatigue Assessment Score | 3 months after discharge | 10-50 score. The higher the score, the more fatigue |
| Cognitive sore (MOCA) | 3 months after discharge | 0-30. The lower the score, the more cognitive impairment |
Countries
Denmark
Outcome results
None listed