Down Syndrome, Dysphagia, Oropharyngeal
Conditions
Keywords
oscillometry, spirometry, outcomes
Brief summary
The goal of the study is to learn more about tests that can assess lung health in children with Down syndrome.
Interventions
None listed
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
University of Colorado, Denver
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Children aged 3 to 18 years, inclusive, at time of consent * Diagnosis of Down syndrome/trisomy 21 or mosaicism * Able to walk * Had a swallow study (video fluoroscopic swallow study or fiberoptic endoscopic evaluation of swallowing) performed within 5 years of consent date
Exclusion criteria
* Pregnant or lactating * Nonambulatory * Have a tracheostomy or other known severe glottic or subglottic obstruction that would significantly affect the results of testing * Have a significant acute respiratory illness, defined as treatment with steroids, antibiotics, or an increase in supplemental oxygen * have a medical illness that would a)increase the risk the participate would incur by participating in the study, b) interfere with the outcomes of the study, or c) interfere with the performance of study participants * Have a severe behavioral problem that would interfere with the performance of study procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total airway resistance | Baseline | Airway resistance (R5) measured using forced oscillation technique at 5 Hertz |
| Airway reactance | Baseline | Airway reactance (X5) measured using forced oscillation technique at 5 Hertz |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in total airway resistance after albuterol | Baseline | Airway resistance (R5) measured using forced oscillation technique at 5 Hertz before and after administration of albuterol |
| Change in airway reactance after albuterol | Baseline | Airway reactance (X5) measured using forced oscillation technique at 5 Hertz before and after administration of albuterol |
| Health-related quality of life, as measured by the Pediatric Quality of Life Inventory | Baseline | The Pediatric Quality of Life Inventory (PedsQL) assesses four domains of quality of life. Results are converted to a score from 0-100, where low numbers are low quality of life and higher numbers is better quality of life. |
Countries
United States
Contacts
Primary ContactAllison Keck
Backup ContactRawan Jarrar
Outcome results
None listed