Analgesics, Analgesics, Opioid, Morphine, Peripheral Nervous System Agents
Conditions
Keywords
quadratus lumborum block, bupivacaine, cesarean delivery, c-section, intrathecal morphine, post-operative pain, post-cesarean analgesia
Brief summary
The purpose of this study is to assess whether quadratus lumborum (QL) block performed 1 day after cesarean delivery will provide supplemental post-cesarean analgesia and reduce opioid requirements.
Interventions
DRUGSaline
0.9% saline on each side
DRUGBupivacaine
0.25% bupivacaine (50mg) on each side
DRUGDexamethasone
3mg preservative-free dexamethasone on each side
Sponsors
The University of Texas Health Science Center, Houston
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* elective or non-elective cesarean delivery on prior day * pain scores \>5/10
Exclusion criteria
* BMI \>40 * obstructive sleep apnea * drug abuse * chronic pain * chronic opioid use * abdominal surgeries other than cesarean delivery * contraindications to neuraxial or regional anesthesia * received general anesthesia or did not receive neuraxial morphine for cesarean delivery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total opioid consumption | 48 hours after intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Amount of opioids used | at the time of intervention (one day following cesarean delivery) | — |
| Time from quadratus lumborum block until first opioid request | from time of intervention until time of first opioid request (up to 48 hours) | — |
| Pain as measured by an 11-point verbal pain score (at rest) | at the time of intervention (one day following cesarean delivery) | The 11-point verbal pain score ranges from 0-10, with a higher number indicating worse pain. |
| Nausea as measured by a 3-point scale | at the time of intervention (one day following cesarean delivery) | This is measured categorically as none, mild, or moderate-severe. |
| Pain as measured by an 11-point verbal pain score (with movement) | at the time of intervention (one day following cesarean delivery) | The 11-point verbal pain score ranges from 0-10, with a higher number indicating worse pain. |
| Pruritus as measured by a 3-point scale | at the time of intervention (one day following cesarean delivery) | This is measured categorically as none, mild, or moderate-severe. |
| Sedation as measured by a 3-point scale | at the time of intervention (one day following cesarean delivery) | This is measured categorically as none, mild, or moderate-severe. |
| Patient satisfaction as measured by the 5-point Likert scale | 48 hours after intervention | The 5-point scale ranges from extremely satisfied to not satisfied. |
| Nausea, pruritus and sedation as measured by a 3-point scale | 24 hours after intervention | This is measured categorically as none, mild, or moderate-severe. |
Countries
United States
Outcome results
None listed