Hearing Loss, Sensorineural
Conditions
Keywords
cochlear implant, dexamethasone
Brief summary
The protection of cochlear cells is one of the main concerns of cochlear implant surgery. New electrode designs or additional molecules have been used for this purpose. The aim of the study is to test the effect of dexamethasone in two different application methods.
Detailed description
The protection of cochlear cells is one of the main concerns of cochlear implant surgery. New electrode designs or additional molecules have been used for this purpose. The aim of the study is to test the effect of dexamethasone in two different application methods. Participants who will have cochlear implant surgery will be divided into three groups. Group 1 will have intracochlear dexamethasone after the incision of the round window membrane. Group 2 will have intratympanic dexamethasone after the incision of the round window membrane. Group 3 will serve as a control group. All participants will be tested after a week, a month, 3, and 6 months. Impedance and threshold measurements will be compared.
Interventions
DRUGIntracochlear Dexamethasone
intracochlear injection of dexamethasone with cochlear implantation
intratympanic injection of dexamethasone with cochlear implantation
Control group: No drugs will be injected middle ear with cochlear implantation
Sponsors
Pamukkale University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Prospective, randomized
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with sensorineural hearing loss * Patients who will have cochlear implant surgery with CI422 electrode
Exclusion criteria
* Patients with cochlear abnormality * Patients with auditory neuropathy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Electrode Impedance(Ohm) | 1-3 months | All intra-operative impedance values will be acquired after surgery. They will be repeated in first and 3 rd months |
| Electrode thresholds(CL) | 1-3 months | All intra-operative thresholds will be acquired after surgery. They will be repeated in first and 3 rd months |
Countries
Turkey (Türkiye)
Outcome results
None listed