Pneumonia
Conditions
Keywords
pneumonia, sepsis, body composition
Brief summary
We hypothesize that serial changes of body composition in patients with pneumonia can help clinician to monitor prognosis. It was associated with underlying immune response.
Detailed description
Specific aims: 1. Can serial body composition data be useful for predicting outcomes of patients with pneumonia? (developing sepsis, organ failure, admission to ICU, length of ICU, survival, length of stay in hospital, prolonged mechanical ventilation,..) 2. Can serial body composition data be integrated into both immune status alternatives (e.g., white blood cell (WBC) count, segment/monocyte ratio, pulse pressure) in such critical illness and monitoring responses (SOFA score, labs) for severe pneumonia patients? 3. Can serial body composition data reflect clinical variables in patients with pneumonia, and even altered by nutrition intake? (e.g., compare association between nutrition intake amount and groups stratified by body composition, blood pressure, nutritional intake, …)
Interventions
DEVICEnoninvasively Bio-electrical Impedance Analysis (BIA)
By means of noninvasively Bio-electrical Impedance Analysis (BIA) to measure body composition, which divides body weight into different components such as lean body mass and fat mass.
Sponsors
Chang Gung Memorial Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adult patients with pneumonia admitted to the thoracic ward or medical intensive care unit of Kaohsiung Chang Gung Memorial Hospital
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ICU Days | During hospitalization， through study completion, an average of 1 year | length of stay in ICU |
| Ventilation days | up to 24 weeks | days of mechanical ventilation |
| sepsis free days | up to 24 weeks | the cure day of sepsis |
| mortality | During hospitalization， through study completion, an average of 1 year | death rate |
| Change in Total Body Water | Change from Baseline Total Body Water at day 8 | Change in Total Body Water |
| Change in Percentage of Body Fat | Change from Baseline Percentage of Body Fat at day 8 | Change in Percentage of Body Fat |
| Change in Soft Lean Mass | Change from Baseline Soft Lean Mass at day 8 | Change in Soft Lean Mass |
| Change in segment/monocyte ratio | Change from Baseline Segment count to monocyte count ratio at day 8 | Change in Segment count to monocyte count ratio |
Countries
Taiwan
Outcome results
None listed