Effect of Processed Blueberry on Blood Glucose and Antioxidant Status in Human Adults

Effect of Hydro-Thermodynamic (HTD) Processed Blueberries on Postprandial Blood Glucose Control and Antioxidant Status in Human Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04396262

Enrollment

Registered

2020-05-20

Start date

2015-11-01

Completion date

2022-08-31

Last updated

2023-03-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Glucose

Keywords

Blueberry, Blood Glucose, Antioxidants, Hydro-Thermodynamic Processing, Beverages

Brief summary

Canada's Food Guide (2007) recommended 7-10 servings of fruits and vegetables per day for a normal adult population. Although fruit juice (125 ml) is considered as one serving of fruits, the consumption of some fruit juices may be limited due to their high amount of sugar. The consumption of sugary drinks can lead to a rapid rise in postprandial glycaemia. Wild blueberries, due to their high level of anthocyanins, may provide multiple health benefits including improved blood glucose control, however, the consumption of fresh berries is limited by their short seasonal availability. Hydro-Thermodynamic (HTD) processing of blueberries allows the processing of whole berries including their skin and seeds into a beverage with the amount of anthocyanins comparable with fresh berries. The objective of the study is to investigate the effect of HTD-processed blueberries on postprandial glycaemia and antioxidant activity.

Interventions

OTHERFood-1

HTD-blueberry beverage with white bread.

OTHERFood-2

Sweetened water with white bread as a control.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy adults * Body mass index (BMI) within normal range (18.5-24.9 kg/m2 for adults)

Exclusion criteria

* Chronic metabolic diseases or inflammatory conditions * Smokers * A medication that influences glucose control or gastrointestinal function * Known allergies * Intellectual disabilities

Design outcomes

Primary

Measure	Time frame	Description
Blood glucose	0-120 min	The concentration of glucose in venous blood after consuming HTD-blueberry beverage with white bread or water control with white bread.

Secondary

Measure	Time frame	Description
Postprandial antioxidant activity in blood	0-120 min	The total antioxidant activity in blood plasma determined using a commercial Antioxidant Assay Kit.

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026