CORONAVIRUS INFECTIONS
Conditions
Brief summary
Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis (Limit : 5000 characters) The management of critically-ill patients with organ failure due to COVID-19 represents a major healthcare burden. While endothelial inflammation has been reported in these patients, the pathophysiological mechanisms remain incompletely elucidated.
Detailed description
Extended description of the protocol, including more technical information (as compared to the Brief Summary) if desired. Do not include the entire protocol; do not duplicate information recorded in other data elements, such as eligibility criteria or outcome measures. (Limit : 32 000 characters) The soluble fms-like tyrosine kinase 1 (SFlt1) is the soluble form of VEGF-A receptor 1 (VEGFR1). By linking VEGF-A with a high affinity, sFlt1 blocks the VEGF-A / VEFR1 axis and impairs endothelial homeostasis. Its production increases during inflammation. We hypothesize that sFlt1 is upregulated and correlates with endothelial dysfunction and outcomes in critically-ill patients with COVID-19.
Interventions
OTHERmeasurement of circulating sFlt1 concentration
blood circulating sFlt1 concentration will be determined
Sponsors
CHU de Reims
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with documented COVID-19 (positive PCR) * Hospitalized in University Hospital of Reims * Patient or family who have previously consented
Exclusion criteria
* Patient \<18 yo * Patient not insured under the French social security
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association between concentration of circulating sFlt1 and use of vasopressor | 14 days |
Countries
France
Outcome results
None listed