Alveolar Bone Loss
Conditions
Brief summary
The reduction in alveolar bone dimensions is an inevitable outcome after tooth extraction due to the healing events that results in bone modeling/remodeling. Alveolar ridge preservation is a successful approach that aids in reducing these changes greatly. Various techniques have been employed to achieve that outcome utilizing bone grafts and/or membrane. Dentin graft is a promising type that can overcome many of the limitations facing mainstream grafts. Autogenous source serve the advantage of providing graft with no cross-infection risk or immunogenicity. Moreover, the unique structure of dentin makes it suitable for osteoinduction and osteoconduction that yields favorite bone regeneration outcomes. Demineralization of dentin is essential to release trapped growth factors, expose collagen fibrils and enhance the grafts degradability and replacement by native tissues. Many acids have been investigated for the use in chairside preparation of the dentin graft and hence, clinicians are faced with different choices but little evidence regarding the acid which yield s better outcomes.
Interventions
atraumatic extraction followed by graft material insertion
Sponsors
Study design
Intervention model description
Split-mouth prospective randomized clinical trial with 1:1 assignment
Eligibility
Inclusion criteria
* Non-restorable teeth * medically healthy * able to provide informed consent and attend follow-up period
Exclusion criteria
* pregnant * smokers or alcoholic * severe bone loss
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiographic bone changes | 6 months | width and height losses (quantitative in mm) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| histological analysis | 6 months | Histologic observations (qualitative) and histomorphometric measurements (quantitative in %) |
| soft tissue healing | Biweekly for 6 weeks | rate of wound epitheliallization |