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Demineralized Dentin Graft With Hydrochloric Acid Versus Nitric Acid in Alveolar Ridge Preservation

Demineralized Dentin Graft With Hydrochloric Acid Versus Nitric Acid in Alveolar Ridge Preservation. Randomised Controlled Clinical Trial

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04393714
Acronym
DDG
Enrollment
8
Registered
2020-05-19
Start date
2020-10-01
Completion date
2021-10-31
Last updated
2020-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alveolar Bone Loss

Brief summary

The reduction in alveolar bone dimensions is an inevitable outcome after tooth extraction due to the healing events that results in bone modeling/remodeling. Alveolar ridge preservation is a successful approach that aids in reducing these changes greatly. Various techniques have been employed to achieve that outcome utilizing bone grafts and/or membrane. Dentin graft is a promising type that can overcome many of the limitations facing mainstream grafts. Autogenous source serve the advantage of providing graft with no cross-infection risk or immunogenicity. Moreover, the unique structure of dentin makes it suitable for osteoinduction and osteoconduction that yields favorite bone regeneration outcomes. Demineralization of dentin is essential to release trapped growth factors, expose collagen fibrils and enhance the grafts degradability and replacement by native tissues. Many acids have been investigated for the use in chairside preparation of the dentin graft and hence, clinicians are faced with different choices but little evidence regarding the acid which yield s better outcomes.

Interventions

PROCEDUREAlveolar ridge preservation after extraction

atraumatic extraction followed by graft material insertion

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)

Intervention model description

Split-mouth prospective randomized clinical trial with 1:1 assignment

Eligibility

Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

* Non-restorable teeth * medically healthy * able to provide informed consent and attend follow-up period

Exclusion criteria

* pregnant * smokers or alcoholic * severe bone loss

Design outcomes

Primary

MeasureTime frameDescription
Radiographic bone changes6 monthswidth and height losses (quantitative in mm)

Secondary

MeasureTime frameDescription
histological analysis6 monthsHistologic observations (qualitative) and histomorphometric measurements (quantitative in %)
soft tissue healingBiweekly for 6 weeksrate of wound epitheliallization

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026