Para Aortic Lymphadenectomy : Always ?

Assesment of Paraaortic Lymphadenectomy in Locally Advanced Cervical Cancer, When no Pathologic Pelvic Lymph Node on PET/CT: Retrospective Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04392895

Acronym

PALA

Enrollment

160

Registered

2020-05-19

Start date

2017-01-01

Completion date

2020-06-30

Last updated

2020-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical Cancer

Keywords

Locally advanced cervical cancer, more than IB3 stage FIGO 2018, Para aortic lymphadenectomy, Laparoscopy, PET/CT

Brief summary

Cervical cancer affects more than 3000 new cases per year in France. The treatment of stage IB3 to IVA cervical cancer is based on concomitant radio-chemotherapy. The irradiation volumes are based, according to current recommendations, on imaging examinations and / or on the results of a laparoscopic Para-aortic lymphadenectomy (PAL). There is some risk of false negatif with the PET/CT. For this reason, most of the time, PAL is offered when there is no pathological paraaortic lymph node on PET/CT. The investigators suppose that this staging surgery could be avoid when no pathological pelvic nodes are identified on PET/CT. The investigators use a retrospective study, to analyse histological report of systematic PAL, comparing to results of pre-operative PET/CT.

Interventions

PROCEDUREPara Aortic Lymphadenectomy (PAL) by laparoscopy

Para Aortic Lymphadenectomy (PAL) by laparoscopy

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

\- Patients with : * locally advanced cervical cancer, * who undergone PAL * with pre operative PET CT, between January 2015 and december 2019

Exclusion criteria

\- patients aged under 18

Design outcomes

Primary

Measure	Time frame	Description
negative predictive value of PET/CT on para aortic nodes when no pathological pelvic nodes.	1 day	negative predictive value of PET/CT on para aortic nodes when no pathological pelvic nodes. The intraoperative 3D optical scan gives the tumor localization obtained by radioguided occult lesion localization thanks to pen marking left by the surgeon. The comparison is done by superimposing both acquisitions.

Secondary

Measure	Time frame	Description
morbidity of PAL	1 day	morbidity of PAL

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026