SARS-CoV 2
Conditions
Keywords
Intensive Care, Invasive Mechanical Ventilation, Body Mass Index, Obesity
Brief summary
This study will involve collection of pseudonymized data from hospital-based data reporting at multiple international sites. Collating data from a large volume of patients with COVID-19 admitted in ICU across multiple international sites will enable investigation of whether obesity is a risk factor for complicated from of SARS-CoV-2 in adult patients and whether this association is independent of other cardiometabolic risk factors.
Detailed description
The COVID-19 pandemic is characterized by a high frequency of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), who often require invasive mechanical ventilation (IMV). Body mass index (BMI) was however rarely mentioned in early clinical reports. Disease severity gradually increased with body mass index (BMI) categories among patients admitted in intensive care unit (ICU) for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the need for invasive mechanical ventilation (IMV), reaching 85% in patients with class II or III obesity ( BMI \> 35 kg/m2). In summary, there is an urgent need for more evidence on the specific role played by obesity in the development of COVID-19 complications, and more particularly of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
Interventions
OTHERPatients admitted to Intensive Care Unit with SARS-CoV2
Patients admitted to Intensive Care Unit with SARS-CoV2
Sponsors
University Hospital, Lille
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participant is aged 18 years or over * Has been admitted to ICU with COVID-19 disease. * COVID-19 disease has been confirmed by PCR for SARS-CoV-2 * Height and weight or BMI on admission has been recorded * Data has been collected in an ethical manner as part of a national database or clinical auditing process approved by the local institution or collaboration
Exclusion criteria
-There are no
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relationship between body mass index (BMI) and SARS-CoV-2 | 3 months | The primary objective of this study is to investigate the relationship between obesity, as determined by body mass index (BMI), and severe pneumonia, as defined by the need of invasive mechanical ventilation ( IMV), among patient admitted in ICU for SARS-CoV-2, across multiple centers, in multiple countries. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Associations between BMI and outcomes is independent of the known cardiometabolic risk factors | 3 months | Investigate whether the associations between BMI and outcomes is independent of the known cardiometabolic risk factors, hypertension, diabetes, dyslipidemia, and current smoking. |
| Investigate the modifying effects of age and sex on the associations between BMI and outcome: Invasive mechanical ventilation | 3 months | Investigate the modifying effects of age and sex on the associations between BMI and outcome: Invasive mechanical ventilation |
| Investigate the modifying effects of age and sex on the associations between BMI and outcome: mortality | 3 months | Investigate the modifying effects of age and sex on the associations between BMI and outcome: mortality |
Countries
France
Outcome results
None listed