ARDS, Human, Humidifier Lung, Mechanical Ventilation Complication
Conditions
Brief summary
Clinical evaluation of a new educative tools (Smartphone application) based on impact of instrumental dead space reduction after initiation of protective ventilation during mechanical ventilation.
Interventions
PROCEDUREProtective ventilation implementation
In this condition, we will implement the protective ventilation related with gender and height . A blood gas will be performed at before protective ventilation implementation and at the end of this condition.Time condition 30 minutes
PROCEDUREProtective ventilation with HME
In this condition, the patient will received protective ventilation with a Heat Moisture Exchanger (HME). A blood gas will be performed at the end of this condition.Time condition 30 minutes
PROCEDUREProtective ventilation with Heated humidifier
In this condition, the patient will received protective ventilation with a Heated humidifier. A blood gas will be performed at the end of this condition.Time condition 30 minutes
PROCEDURETidal Volume reduction
n this condition, we will reduce Tidal volume (with smartphone application calculation) to obtain the same alveolar ventilation (PaCO2) obtained on the HME condition
Sponsors
Laval University
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years old * Mechanical ventilation (control,assist control or SIMV mode) * haemodynamic stability (vasopressor \< 0.2 ug/kg/min) * no prone position schedule in the next 2 hours following procedure inclusion * presence of an Arterial catheter
Exclusion criteria
* ECMO or anticipate ECMO * body temperature \< 36.0 for post operative patient (cardiac surgery)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PaCO2 Variation | 60 minutes post intervention | The primary outcome is to evaluate the PaCO2 variation at the end of condition 2 (after 30 minutes with protective ventilation+ HME) and condition 4 (30 minutes after Tidal volume reduction + Heater humidifier). Variation \<= 10% of PaCO2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between PCO2 variation and alveolar ventilation variation | 60 and 90 minutes post intervention | We will compare PaCO2 level variation and the alveolar ventilation variation to establish correlation. Correlation variation under 10% will be significative |
| Hemodynamic impact vs pH | Baseline, 30, 60, 90 and 120 minutes post intervention | Cardiac echographic measurement (LeftVentricularEjectionFraction) in relation with acidosis status |
Countries
Canada
Contacts
Primary ContactFrançois Lellouche
Outcome results
None listed