Patients Undergoing Cardiac or Thoracic Surgery
Conditions
Keywords
Cardiac surgery, Postoperative outcome, COVID-19, SARS-Cov 2 infection, Postoperative complication
Brief summary
This study will describe the recovery process of patients undergoing cardiac surgery during the covid-19 pandemic. This will focus on hemodynamic failure and organ dysfunction after surgery. Capturing real-world data and sharing international experience will inform the management of this complex group of patients who undergo surgery throughout the COVID-19 pandemic, improving their clinical care. This investigator-led, non-commercial, non-interventional does not collect any patient identifiable information.
Detailed description
Performing cardiac surgery in the context of SARS-CoV2 infection is potentially at risk of marked post-operative hemodynamic failure (shock) due to the inflammatory reaction generated by the surgery and the extracorporeal circulation associated with the viral infection. In addition, in the absence of infection, 30-50% of patients will experience acute post-operative respiratory failure due to the combined effects of extracorporeal circulation and general anesthesia. The pulmonary tropism of the virus therefore is susceptible to increase in post-operative respiratory impairment. Thus, the infection is likely to favor the occurrence of post-operative shock but also to aggravate respiratory failure and other post-operative organ failures. Therefore, the investigators designed an observational study that aims at comparing two groups of patients: * Cardiac or thoracic surgery patients with a negative Covid-19 PCR pre-operatively and in the 15 following days * Cardiac or thoracic surgery patients with a positive Covid-19 PCR in the 15 days before surgery
Interventions
No description
Sponsors
Study design
Eligibility
Inclusion criteria
* Adults (age ≥18 years) undergoing cardiac or thoracic surgery * With positive PCR in the 5 days before or after cardiac/thoracic surgery.
Exclusion criteria
* Minors
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Highest VIS (Vasoactive-Inotropic Score) in the first 12 hours postoperatively. | 12 hours post-operatively | The VIS score correlates with mortality after cardiac surgery and reflects the degree of patient hemodynamic failure. This score is calculated as follows: ISR = Dobutamine dose in g/kg/min + 100 times the Adrenaline dose in g/kg/min + 100 times the Noradrenaline dose in g/kg/min + 10,000 times the Vasopressin dose in U/kg/min. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Post-operative organ failure | 5 days post-operatively | Prospective assessment of ICU outcomes until all included patients were discharged from ICU |
| Post-operative outcome | 28 days post-operatively | Prospective assessment of ICU outcomes until all included patients. |
Countries
France