Chronic Apical Periodontitis
Conditions
Keywords
Apicomarginal defects, Cone Beam Computed Tomography, Autologous platelet aggregate
Brief summary
This study will evaluate the effect of PRF (platelet rich fibrin) on the healing of apicomarginal defects. Healing of the defects will be assessed 2 dimensionaly by periapical radiograph and 3 dimensionaly using CBCT.
Detailed description
Patients with apicomarginal defects as per the inclusion criteria will be randomly divided into two groups - (1) Test group - The denuded root surface will be covered by PRF (Choukron's method) and (2) Control group -No use of autologous platelet aggregate during periapical surgery. Radiographic and clinical healing will be assessed after 12 months, 2D healing will be assessed by Rud and Molven criteria and 3D healing will be assessed by Modified Penn 3D criteria.The clinical parameters recorded including periodontal pocket depth (PD), clinical attachment level (CAL) and gingival margin position (GMP) will be measured on buccal aspect of the interproximal space and mid buccal aspect of the involved teeth using Williams 'O' periodontal probe.Routine examination procedure will be used to evaluate any evidence of signs and/or symptoms.
Interventions
PROCEDUREPeriapical surgery using autologous platelet aggregate
PRF will be placed over the denuded root surface, following apicoectomy and before flap repositioning
PROCEDUREPeriapical surgery without autologous platelet aggregate
Flap will be repositioned following apicoectomy directly without placing any platelet aggregate
Sponsors
Postgraduate Institute of Dental Sciences Rohtak
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Double
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* A negative response to vitality tests with radiographic evidence of periapical radiolucency with no general medical contraindications for oral surgical procedures. * Apicomarginal communication having probing depth \> 6mm. * Patients with no general medical contraindications for oral surgical procedures. * Recurrent episodes of purulent discharge. * Failed previous root canal treatment. * Failed previous surgery with persistent bony lesion. * Adequate final restoration with no clinical evidence of coronal leakage.
Exclusion criteria
* Clinical or radiographic evidence of root fracture. * Resorptive processes involving more than apical third of the root. * Any systemic disease contraindicating oral surgery including uncontrolled diabetes and pregnancy. * Any condition effecting rate of healing like smoking.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in periapical radiolucency | Baseline to 12 Months | 2 blinded caliberated operators will score the periapical radiolucency at baseline and 12 months by following scoring scores for 2D healing Score1-Complete healing defined by re-establishment of the lamina dura Score 2- Incomplete healing (scar tissue) Score 3- Uncertain healing Score 4- Unsatisfactory healing scores for 3D healing Score1- Complete healing Score 2- Limited healing Score 3- Uncertain healing Score 4- Unsatisfactory healing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical success | Baseline to 12 Months | Clinical success will be assessed by absence of clinical signs and symptoms such as pain, swelling , sinus or tenderness on palpation or percussion |
Countries
India
Contacts
Primary ContactDR PANKAJ SANGWAN
Backup ContactANKITA RAMANI
Outcome results
None listed