Obesity
Conditions
Brief summary
This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation. It is hypothesized that acute dietary supplementation with grape seed extract attenuates aortic stiffness, systolic blood pressure, diastolic blood pressure, mean arterial pressure, and total peripheral resistance and these effects are partially due to reductions in peripheral vasoconstriction
Detailed description
Twenty men (obese = 10; normal body weight (NBW) = 10) participated in this study. Effects of placebo (PL: 600 mg) and GSE (600 mg) on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total peripheral resistance (TPR), and AoS were compared 2 h after ingestion of GSE or PL on different days, one week apart. Arterial blood pressure was measured using a sphygmomanometer from a brachial artery at the level of the heart on chair. HR and SV were continuously measured using a non-invasive device (Physio Flow). CO was calculated by HR X SV. TPR was calculated by MAP/CO.
Interventions
DIETARY_SUPPLEMENTGrape seed extract
Two capsule grape seed extract (total 600 mg)
Sponsors
California Baptist University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Masking description
Double blind, cross-over design
Eligibility
Sex/Gender
MALE
Age
18 Years to 29 Years
Healthy volunteers
Yes
Inclusion criteria
* Obesity: body mass index (\>30), Normal body weight: body mass index (25-29)
Exclusion criteria
* cardiovascular diseases or consume any antihypertensive medication or supplementation that can affect blood pressure or aortic stiffness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in heart rate | 2 hours after each supplementation | beats per minute |
| change in stroke volume | 2 hours after each supplementation | volume per stroke |
| change in cardiac output | 2 hours after each supplementation | total volume for a minute |
| change in systolic blood pressure | 2 hours after each supplementation | pressure exerted during contraction |
| change in diastolic blood pressure | 2 hours after each supplementation | pressure exerted during relaxation |
| change in mean arterial pressure | 2 hours after each supplementation | One reported pressure (systolic blood pressure-diastolic blood pressure)/3 + diastolic blood pressure |
| change in total peripheral resistance | 2 hours after each supplementation | One reported value (mean arterial pressure/cardiac output) |
Countries
United States
Outcome results
None listed