Dementia, Disorientation, Magnetic Resonance Imaging, Mild Cognitive Impairment, Older Adults
Conditions
Brief summary
The purpose of this study is to investigate whether markers of brain structure and function from MRI are associated with different levels of spatial orientation and gait parameters in people with mild cognitive impairment or dementia due to Alzheimer's disease when walking through a real world environment.
Detailed description
This is an experimental cross-sectional study which primarily aims at identifying characteristic features of spatial disorientation among people with mild cognitive impairment and dementia. The features of interest are motion and physiological related changes that occur during instances of spatial disorientation, which will be derived from wearable sensors. Additionally, brain structure and functional connectivity changes associated with different levels of spatial orientation and gait parameters will also be investigated through resting-state functional imaging.
Interventions
None listed
Sponsors
German Center for Neurodegenerative Diseases (DZNE)
University Medical Center Rostock
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 50 years and above * Mini mental state examination (MMSE) ≥ 12 \< 28 points for experimental group * Mini mental state examination (MMSE) ≥ 28 points for control group * Sufficient knowledge of German to understand participant information, declaration of consent and questionnaires * Dated and signed declaration of consent * Sufficient mobility and motivation to participate in the study
Exclusion criteria
* Less than 50 years * Significantly impaired vision or hearing * Severely reduced mobility: cannot move around independently (even with aids)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spatial disorientation | Up to 3 years from start of the study | Incidences of disorientation will be annotated in real-time using a customized annotation scheme in the pocket observer software |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Skin conductance | Up to 3 years from start of the study | Rate of change in electrodermal response will be measured using a wearable electrodermal activity sensor |
| Accelerometry | Up to 3 years from start of the study | Incidences of change in movement behaviour and activity level will be measured using accelerometers |
| Grey matter volume | Up to 3 years from start of the study | Rate of change in brain structural volume will be measured using a 3-Tesla scanner |
| Heart rate variability | Up to 3 years from start of the study | Rate of change in heart rate will be measured using a wearable Photoplethysmography sensor |
| Resting-state functional connectivity | Up to 3 years from start of the study | Rate of change in functional connectivity of resting-state brain networks will be measured using a 3-Tesla scanner |
| Interview responses | Up to 3 years from start of the study | Participants assessments of their sense of orientation are obtained using a structured interview. |
| White matter integrity | Up to 3 years from start of the study | Rate of change in structural connectivity of brain white matter will be measured using a 3-Tesla scanner |
Countries
Germany
Contacts
Primary ContactChimezie O Amaefule, M.Sc
Outcome results
None listed