Drip-infusion of Remifentanil for RIH

Postoperative Drip-infusion of Remifentanil for Preventing Remifentanil-induced Hyperalgesia- a Retrospective Observative Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04387097

Enrollment

559

Registered

2020-05-13

Start date

2018-05-01

Completion date

2019-07-22

Last updated

2020-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperalgesia

Keywords

Remifentanil, Hyperalgesia, Drip-infusion

Brief summary

The development of remifentanil-induced hyperalgesia (RIH) is an unpleasant experience for surgical patients. An alternative management, gradual withdrawal of remifentanil was effective in prevention of RIH. The investigators designed a simple modality to assess if under withdrawal of remifentanil and further drip-infusion of remifentanil immediately after extubation affected postoperative pain score, the requirement of rescue analgesics, and adverse effects.

Detailed description

In clinical practice, the gradual withdrawal of remifentanil during surgery is unsatisfied. Thus, the investigators conducted a simple modality in a single center retrospective cohort study to assess how under baseline gradual withdrawal of remifentanil and further drip infusion of remifentanil immediately after extubation affected postoperative pain score and use of analgesics.

Interventions

DRUGremifentanil

postoperative drip-infusion of remifentanil

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* American Society of Anesthesiologists (ASA) score of I-III patients receiving total intravenous anesthesia

Exclusion criteria

* The use of inhalation agents or propofol combined with inhalation anesthesia * Pregnancy * Previous substance abuse * Known allergies to opioids, propofol or any drugs used in the study * History of neuropsychiatric disorder * Age \< 20 years or \> 80 years

Design outcomes

Primary

Measure	Time frame	Description
comparison of the numeric rating scale (NRS) between 2 groups	one hour	NRS scores is labeled from zero to ten, with zero being an example of someone with no pain and ten being the worst pain possible.
requirement for rescue analgesics	one hour	postoperative requirement for rescue analgesics

Secondary

Measure	Time frame	Description
type of surgery	three hours	type of surgery in both groups
surgical site	three hours	surgical site in both groups

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026