Enterovirus Infection During Perinatal Period
Conditions
Brief summary
Neonates could be infected by non-polio enterovirus easily. Some of the neonates may develop fatal complications within one week. The objective of this study were as following: 1.To understand the composition and epidemiological characteristics of enterovirus infection in pregnant women in some areas of China; 2.To understand the transmission from mother to their neonates; 3.To understand the pathogenic spectrum composition, epidemiological characteristics and clinical characteristics of enterovirus infection in neonates; 4.To understand the genetic variation and changes of enteroviruses; 5.To establish a quality management system for maternal and neonatal enterovirus laboratory testing and monitoring.
Interventions
OTHERNo intervention
No intervention
Sponsors
Bayi Children's Hospital Affiliated to PLA Army General Hospital, China
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 60 Years
Healthy volunteers
No
Inclusion criteria
* 1\. General parturient: on the first day of the third week of each month, all parturients and their newborns admitted to the hospital (day shift 8:00-18:00) within that day; 2. Puerpera with fever: all puerperas with fever (body temperature \>=37.5 degree C) and their newborns were included in summer and autumn (from May); 3. Febrile newborns: those included in summer and autumn (from May) with the following clinical characteristics: fever \>=37.5 degree C, lasting for more than one day. And sign the informed consent form with the consent of the guardian.
Exclusion criteria
* 1\. Pregnant women with urinary tract infection, chorioamnionitis and bacterial infection; 2. Puerpera with fever due to urinary tract infection, chorioamnionitis and bacterial infection; 3. Newborns infected with other pathogens.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection of enterovirus | 42 days | Detection of the rate of enterovirus infection and identify the genotype of enterovirus. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Detection of antibodies of enterovirus | 42 days | Detection of IgG antibodies of enterovirus |
Countries
China
Contacts
Primary ContactZhichun Feng, Prof
Backup ContactLu Zhuang, PhD
Outcome results
None listed