GH, Poor Ovarian Reserve Based on POSEIDON
Conditions
Keywords
growth hormone, POSEIDON, low ovarian reserve, prospective observational cohort study
Brief summary
It is still a big difficult clinical problem for patients with poor ovarian reserve undergoing in vitro fertilization. The decrease in both quality and quantity of egg are the main cause for poor clinical prognosis. Growth hormone (GH) is currently one of the main adjuvant for improving pregnancy outcomes in patients with POR, and the investigators' previous retrospective study suggested GH was effective in live birth rate in subgroup of patients with POR older than 35 years old. To further figure out the mechanism of GH effectiveness in POR patients and the effect on clinical outcomes in POR patients, the investigators designed this prospective observational cohort study.
Interventions
DRUGgrowth hormone
growth hormone was adjuvanted 2IU/d from previous menstrual period for about six weeks.
Sponsors
Guangzhou First People's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
For patients with poor ovarian response, the criteria is based on POSEIDON criteria\[1\]: 1. low ovarian reserve(AMH \<1.2ng/ml, or AFC \<5); 2. younger than 40. For patients with normal ovarian reserve, the criteria is as follow: 1. Patients who are between 20-40 years old; 2. clinical diagnosis of non-functional fallopian tube; 3. regular menstrual cycles.
Exclusion criteria
1. BMI ≥28kg/m2; 2. medical diseases such as endocrine and metabolic diseases, autoimmune disease, etc; 3. ovarian neoplasm that ≥4 cm in diameter and has no clear pathological diagnosis by surgery; 4. adenomyosis or endometriosis confirmed by surgery; 5. untreated abnormal intrauterine environment, such as uterine effusion, endometritis, etc; 6. untreated hydrosalpinx; 7. polycystic ovary syndrome.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clinical pregnancy rate | 1-2 years | Clinical pregnancy means pregnancy sac is seen intrauterine under ultrasound 7 weeks after embryo transferred. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| live birth rate | 1-2 years | Live birth rate(%): number of live birth/ transferred cycle. |
| number of oocytes retrieved | 1-2 years | number of oocytes retrieved on day of OPU |
Other
| Measure | Time frame | Description |
|---|---|---|
| telomerase activity of granulosa cells | 1-2 years | detection of telomerase activity of granulosa cells in wasted follicular fluid |
Contacts
Primary Contactmeihong Cai, master
Outcome results
None listed