Acute Respiratory Distress Syndrome, COVID-19, Extracorporeal Membrane Oxygenation Complication
Conditions
Brief summary
This study aims to investigate outcomes and predictors of outcome after extracorporeal membrane oxygenation (ECMO) therapy for severe acute respiratory syndrome (ARDS) in COVID-19 patients.
Detailed description
We evaluated the outcome of adult patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) requiring the use of extracorporeal membrane oxygenation (ECMO).
Interventions
DEVICEExtracorporeal membrane oxygenation
Veno-venous or veno-arterial extracorporeal oxygenation
Sponsors
Helsinki University Central Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* PCR-confirmed or suspected COVID-19 infection with ARDS who require any ECMO therapy
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| In-hospital mortality | Immediately after the intervention/procedure/surgery | All-cause mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Stroke | Immediately after the intervention/procedure/surgery | Stroke was defined as any focal or global neurological syndrome caused by ischemia and/or hemorrhage not resolving within 24 hours. |
| Blood stream infection | Immediately after the intervention/procedure/surgery | Blood stream infection detected on blood cultures |
| Lung complications requiring surgical treatment | Immediately after the intervention/procedure/surgery | Pneuthorax, pneumonia and/or abscess requiring surgical treatment |
| Blood transfusion | Immediately after the intervention/procedure/surgery | Transfusion of red blood cells |
| Acute kidney injury | Immediately after the intervention/procedure/surgery | Acute renal failure according to the Kidney Disease: Improving Global Outcomes classification (KDIGO) criteria |
| Death on ECMO | During the intervention/procedure/surgery | Death during ECMO therapy |
| Deep vein thrombosis | Immediately after the intervention/procedure/surgery | Thrombosis of lower limb deep venous system |
| Pulmonary embolism | Immediately after the intervention/procedure/surgery | Pulmonary embolism |
| Length of intensive care unit stay | Immediately after the intervention/procedure/surgery | Length of stay in the intensive care unit |
| Length of hospital stay | Immediately after the intervention/procedure/surgery | Length of hospital stay |
| Death after hospital discharge | Up to 6 months | All-cause death |
| Duration of mechanical ventilation | During index hospital stay follow-up until 1 year after ECMO initiation | Duration of mechanical ventilation |
Countries
Finland, France, Germany, Italy, Sweden, United Kingdom
Outcome results
None listed