Relationship Between LRG and Periodontal Disease

Leucin-rich alpha2 Glycoprotein (LRG): A Novel Acute Phase Protein Related With Stage 3 Periodontitis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04383561

Enrollment

Registered

2020-05-12

Start date

2019-09-30

Completion date

2020-02-15

Last updated

2020-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis, Acute-Phase Response, Inflammation

Keywords

periodontitis, gingival crevicular fluid, serum

Brief summary

This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.

Detailed description

Twenty-five stage 3 periodontitis and twenty-five periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were obtained at baseline and at 6 weeks after treatment. LRG, IL-6 and TNF-α were determined by ELISA.

Interventions

OTHERNon-surgical periodontal treatment

Scaling and root planing (SRP), in four clinical visits

OTHEROral hygiene instructions

Oral hygiene instructions includes brushing with the modified Bass technique, interdental cleaning with dental floss and interdental brushes.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

26 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

1. 25-50 years of age 2. having at least 20 natural teeth, excluding third molars 3. having no systemic disease 4. non-smokers 5. criteria for healthy control group: BOP \< 10% and PD ≤ 3 mm without clinical attachment loss or radiographic sign of alveolar bone destruction 6. criteria for stage 3 periodontitis group: interdental CAL ≥ 5 mm at least 2 non-adjacent teeth, PD ≥ 6 mm and radiographic bone loss extending to the mid-third of the root or beyond.

Exclusion criteria

1. having any systemic diseases, 2. smoking 3. current pregnancy or lactation 4. a history of periodontal treatment in the past 6 months 5. using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.

Design outcomes

Primary

Measure	Time frame	Description
Changes in the levels of biochemical parameters	Baseline and 6 weeks after treatment	The levels LRG, IL-6 and TNF-α were determined to define the diagnostic and prognostic potential as a biomarker in periodontitis.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026