Cross-linking as Treatment in Infectious Keratitis

Standard Cross-linking Versus Accelerated Photoactivated Chromophore Cross-linking (PACK-CXL) for Treatment of Infectious Keratitis: A Comparative Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04383431

Enrollment

Registered

2020-05-12

Start date

2020-06-02

Completion date

2023-01-15

Last updated

2023-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infectious Keratitis

Brief summary

To compare between SCXL and ACXL for treatment of infectious keratitis

Detailed description

Standard epithelium-off CXL, 30 minutes soaking time with riboflavin, 30 minutes UVA corneal irradiation continuous mode (Group A). Accelerated CXL 11 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation pulsed mode (Group B).

Interventions

PROCEDUREPACK-CXL

Standard epithelium-off CXL, 12 minutes soaking time with riboflavin, 8 minutes UVA corneal irradiation pulsed mode.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Fungal infectious keratitis * bacterial infectious keratitis * Must be not responding to medication

Exclusion criteria

* Viral keratitis * Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame	Description
Corneal edema	3 months	measurement of corneal edema by measurement of the corneal thickness in um by Optical Coherent Tomography
Corneal healing	3 months	Reepithelization of corneal ulcer which is measured in mm by slitlamp examination

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026