Glomerular Disease, Renal Disease, Sickle Cell Disease
Conditions
Brief summary
The investigators will attempt to develop a more accurate equation to estimate eGFR in pediatric and adult sickle cell patients
Detailed description
200 pediatric and 200 adult SCA participants will undergo mGFR using iohexol at baseline and at one year. On the same day, participants will undergo clinical and laboratory variables important for developing an eGFR equation. From baseline data, the investigators will perform a training and validation cohort of biologically relevant predictor variables to develop a novel equation. Then the investigators will compare the novel SCA eGFR equation to the established eGFR equation. From one year data, the investigators will determine the longitudinal concordance between pediatric and adult novel and standard eGFR equations with mGFR and variables that may alter longitudinal inferences. In a subset of 30 adult participants, the investigators will also evaluate the correlation between mGFR using iohexol and a novel measure of mGFR that is more time efficient
Interventions
DIAGNOSTIC_TESTiohexol GFR
We will perform mGFR in 400 SCA patients
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
University of Alabama at Birmingham
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* SCA patients (HbSS and SB0 thalassemia) * Age: 5.0-50.0 at enrollment
Exclusion criteria
* Recent SCA complication associated with hospitalization (within 30 days) or ED visit (within 14 days) * Current AKI defined as \>0.3mg/g increase in SCr from prior visit * Known history of anaphylaxis with contrast agent or known pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To develop a novel SCA-specific eGFR equation and compare with existing eGFR equations validated for the general population | 5 years | The investigators will use biologically relevant variables to develop a new equation for eGFR in pediatric and adult sickle cell patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To determine the longitudinal concordance between pediatric and adult novel and standard eGFR equations with mGFR and variables that may alter longitudinal inferences. | 5 years | To compare the concordance between eGFR and mGFR from baseline to one year |
| To test the correlation of the novel mGFR method using VFI FAST and iohexol mGFR. | 5 years | To perform a 3 hour mGFR and compare this mGFR to the 6 hour mGFR (iohexol) |
Countries
United States
Outcome results
None listed