Multiple Sclerosis
Conditions
Keywords
neuroactive steroids, physical therapy, dehydroepiandrosterone, cortisol, multiple sclerosis
Brief summary
This study describes modulation of neuroproprioceptive facilitation and inhibition physical therapy on serum level of neuroactive steroids in multiple sclerosis.
Detailed description
In the parallel group, single blind, randomized controlled trial, participant underwent two kinds of neuroproprioceptive PT (MPAT and VRL). At baseline and after the end of the two months' therapeutic program, a blinded assessor evaluated clinical outcomes and data from serum level.
Interventions
BEHAVIORALNeuroproprioceptive facilitation and inhibition physical therapy
All groups underwent two months' therapy, 16 face-to-face sessions (1 hour, twice a week for two months).
Sponsors
Charles University, Czech Republic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* prevailed spastic paraparesis, stable clinical status and treatment in the preceding 3 months determined by neurologist, * Expanded Disability Status Scale score (EDSS) max. 7.5
Exclusion criteria
* other neurological disease or conditions disabling movement
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum level of neuroactive steroids | 2 months | cortisol, cortisone, 7 alfa-OH-DHEA, 7 beta-OH-DHEA, 7 oxo- oxo-DHEA, DHEA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Berg Balance Scale, BBS outcomes | 2 months | 14 items objective measure of static balance and risk of falls (0 the best, 56 the worse) |
| Paced Auditory Serial Addition Test | 2 months | The PASAT is presented using audio cassette tape or compact disk to ensure standardization in the rate of stimulus presentation. Single digits are presented every 3 seconds and the patient must add each new digit to the one immediately prior to it. |
| the 29-item Multiple Sclerosis Impact Scale, MSIS -29 | 2 months | a 29-item self-report measure with 20 items associated with a physical scale and 9 items with a psychological scale. Items ask about the impact of MS on day-to-day life in the past two weeks. All items have 5 response options: 1 not at all to 5extremely. Each of the two scales are scored by summing the responses across items, then converting to a 0-100 scale where 100 indicates greater impact of disease on daily function (worse health). |
| Modified Fatigue Impact Scale | 2 months | The MFIS is generally presented as a 21-item questionnaire, but there's also a 5-question version. Most people fill it out on their own in a doctor's office. Expect to spend anywhere from five to ten minutes circling your answers. |
Outcome results
None listed