Blepharitis, Demodex Infestation, Meibomian Gland Dysfunction, Pityriasis Folliculorum, Rosacea
Conditions
Keywords
Demodex, Facial Demodicosis, Ocular Demodicosis, Direct Microscopic Examination, Rosacea, Blepharitis, Meibomian Gland Dysfunction, Pityriasis Folliculorum
Brief summary
To understand the association between facial demodicosis and ocular demodicosis, we plan to enroll patients with facial demodicosis, ocular demodicosis, or both, in order to analyze their clinical presentations, the density of Demodex infestation over facial skin and eyelashes, and possible risk factors of the two diagnoses.
Detailed description
Although facial demodicosis and ocular demodicosis are described in a variety of clinical presentations, the association between the two diagnoses is not clearly identified. Clinically, we plan to enroll 120 patients with facial demodicosis, ocular demodicosis. We will obtain their basic information, medical history, medication, and lifestyle. We will evaluate their clinical features. We will also perform quantitative tests including direct microscopic examination and cilia epilation test: 1. Direct microscopic examination: On glabella and bilateral cheeks, follicular contents in the 1-cm × 1-cm area will be squeezed out. The contents are transferred onto a glass slide, covered with mineral oil and a cover slide, and examined under the microscope. 2. Epilation: Four (4) non-adjacent cilia will be pulled from each upper eyelid and examined under the microscope. The total Demodex counts are recorded. We will analyze the clinical presentations, the density of Demodex infestation, and possible risk factors of the two diagnoses.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patient with a diagnosis of facial demodicosis or ocular demodicosis. A. Facial demodicosis defined as both 1 and 2: 1. Clinical presentation of facial skin matches any of the followings: 1. Pityriasis folliculorum. 2. Papulopustular lesion. 3. Rosacea. 2. Demodex infestation detected by direct microscopic examination ≥ 5 mites/cm2. B. Ocular demodicosis defined as both 3 and 4: 3. Clinical presentation of ocular region matches any of the followings: 1. Chronic blepharitis. 2. Eyelash abnormalities: trichiasis, distichiasis, madarosis. 3. Meibomian gland dysfunction. 4. Recurrent chalazion. 5. Ocular rosacea. 4. Demodex infestation detected by cilia epilation test ≥ 1 mite/eyelid.
Exclusion criteria
1. Usage of oral Ivermectin, topical Ivermectin or topical tea tree oil in the past 1 month. 2. Patient who cannot tolerate direct microscopic examination or cilia epilation test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantitative tests of facial and ocular demodicosis | On initial evaluation | Association between the results of direct microscopic examination and cilia epilation test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical features and quantitative tests of facial demodicosis | On initial evaluation | Association between the clinical features and the result of direct microscopic examination |
| Clinical features and quantitative tests of ocular demodicosis | On initial evaluation | Association between the clinical features and the result of cilia epilation |
Countries
Taiwan
Contacts
Primary ContactChang-Ming Huang, M.D.
Outcome results
None listed