The Role of Ultrasound in COVID-19

Conditions

COVID-19

Brief summary

The study is a prospective clinical cohort study of consecutive patients hospitalized at all hospitals of greater Copenhagen with a laboratory confirmed diagnosis of COVID-19. The investigators aim to examine if echocardiography - both conventional and advanced - can be used to predict which patients will develop acute respiratory distress syndrome (ARDS) or other short-term acute complications, especially focusing on cardiovascular outcomes. In addition, using a novel technique of lung ultrasound (LUS), The investigators aim to analyze specific LUS-findings, and associate them with short-term prognosis and development of ARDS and long-term cardiovascular morbidity and mortality. In all patients included, The investigators aim to examine long-term complications at timepoints: 2, 5 and 10 years of follow-up and examine if echocardiography - alone and in combination with biomarkers - can be used to detect early signs of cardiac complications and predict long-term risk of cardiovascular morbidity and mortality following COVID-19 infection

Helena Zander Wodschow, Filip Soeskov Davidovski, Jacob Christensen, Mats Christian Højbjerg Lassen, Kristoffer Grundtvig Skaarup et al. (12 authors)

Frontiers in Nutrition2023-02-094 citations

10.3389/fnut.2023.1131192

Myocardial Work in Patients Hospitalized With COVID‐19: Relation to Biomarkers, COVID‐19 Severity, and All‐Cause Mortality

Flemming Javier Olsen, Mats Christian Højbjerg Lassen, Kristoffer Grundtvig Skaarup, Jacob Christensen, Filip Soeskov Davidovski et al. (33 authors)

Journal of the American Heart Association2022-09-217 citations

10.1161/jaha.122.026571

Lung ultrasound findings following COVID-19 hospitalization: A prospective longitudinal cohort study.

Espersen C, Platz E, Alhakak AS, Sengeløv M, Simonsen JØ, Johansen ND, Davidovski FS, Christensen J, Bundgaard H, Hassager C, Jabbari R, Carlsen J, Kirk O, Lindholm MG, Kristiansen OP, Nielsen OW, Jeschke KN, Ulrik CS, Sivapalan P, Iversen K, Stæhr Jensen JU, Schou M, Skaarup SH, Højbjerg Lassen MC, Skaarup KG, Biering-Sørensen T.

2022-04-029 citations

10.1016/j.rmed.2022.106826

Lung Ultrasound Findings Associated With COVID-19 ARDS, ICU Admission, and All-Cause Mortality

Caroline Espersen, Elke Platz, Kristoffer Grundtvig Skaarup, Mats Christian Højbjerg Lassen, Jannie Nørgaard Lind et al. (26 authors)

Respiratory Care2021-11-2314 citations

10.4187/respcare.09108

Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study.

Skaarup KG, Lassen MCH, Espersen C, Lind JN, Johansen ND, Sengeløv M, Alhakak AS, Nielsen AB, Ravnkilde K, Hauser R, Schöps LB, Holt E, Bundgaard H, Hassager C, Jabbari R, Carlsen J, Kirk O, Bodtger U, Lindholm MG, Wiese L, Kristiansen OP, Walsted ES, Nielsen OW, Lindegaard B, Tønder N, Jeschke KN, Ulrik CS, Lamberts M, Sivapalan P, Pallisgaard J, Gislason G, Iversen K, Jensen JUS, Schou M, Skaarup SH, Platz E, Biering-Sørensen T.

2021-07-022 citations

10.1007/s40477-021-00605-8

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* All patients hospitalized at hospitals of greater Copenhagen area and Zealand with a laboratory confirmed diagnosis of COVID-19 \> 18 years of age.

Exclusion criteria

* Persons not able to cooperate * Persons unable to understand and sign informed consent

Design outcomes

Primary

Measure	Time frame
Incident hypoxic respiratory failure during hospitalization and a confirmed COVID-19 diagnosis	2.5 months
In-hospital mortality during hospitalization and a confirmed COVID-19 diagnosis	2.5 months
Incident ARDS (Adult Respiratory Distress Syndrome) and intensive care unit admission during hospitalization and a confirmed COVID-19 diagnosis	2.5 months

Secondary

Measure	Time frame
Incident stroke after hospital admission with a confirmed COVID-19 diagnosis at follow-up	2.5 months to 10 years
Incident cardiac arrest during hospitalization and a confirmed COVID-19 diagnosis	2.5 months
Incident myocardial infarction after hospital admission with a confirmed COVID-19 diagnosis at follow-up	2.5 months to 10 years
Incident heart failure after hospital admission with a confirmed COVID-19 diagnosis at follow-up	2.5 months to 10 years
Incident pulmonary embolism during hospitalization and a confirmed COVID-19 diagnosis	2.5 months
Death from any cause after hospital admission with a confirmed COVID-19 diagnosis at follow-up	2.5 months to 10 years

Countries

Denmark

Outcome results