Effect of Pineapple Juice on the Pharmacokinetics of Celecoxib and Montelukast in Humans

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04374981

Enrollment

Registered

2020-05-05

Start date

2019-07-01

Completion date

2019-12-01

Last updated

2020-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Food-drug Interaction

Brief summary

Pineapple (Ananas comosus) is a tropical fruit that is rich in antioxidents, enzymes and vitamins. It is used worldwide due to their anti-inflammatory and analgesic properties. The effect of pineapple Juice on the Pharmacokinetics of celecoxib and montelukast in Humans was studied.

Interventions

DRUGCelecoxib 100mg

Tablets

DRUGMontelukast 10mg

Tablets

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy subjects (body mass index between 21 to 25 kg/m2).

Exclusion criteria

* Smokers. * Drug abuse. * Abnormal level of kidney or liver functions.

Design outcomes

Primary

Measure	Time frame
Maximum Plasma Concentration [Cmax]	12 weeks
Time to reach plasma peak concentration [Tmax]	12 weeks
Time to reach maximum plasma concentration [Tmax]	12 weeks
The area under the concentration-time curve from zero to infinity (AUC0-∞)	12 weeks
The terminal elimination half-life (t1/2)	12 weeks

Secondary

Measure	Time frame
Clearance (CLT/F)	12 weeks

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026