Conjunctivitis, COVID-19, Ocular Infection, Viral, Ocular Inflammation, SARS-CoV-2
Conditions
Keywords
conjunctivitis, SARS-CoV-2, COVID-19, Ocular Infection, viral conjunctivitis, ocular inflammation, conjunctival swab, PCR
Brief summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly identified, highly contagious RNA virus causing respiratory infectious disease, Coronavirus Disease 2019 (COVID-19). Conjunctivitis has been reported as a rare finding of the disease, and preliminary studies showed that the virus RNA could be detected in ocular secretions using polymerase chain reaction (PCR) assays when conjunctivitis present. This study aims to estimate the proportion of SARS-CoV-2 associated conjunctivitis among patients with suspected viral conjunctivitis presented to the ophthalmology clinics of Wilmer Eye Institute during the COVID-19 pandemic. The investigators also aim to identify whether SARS-CoV-2 associated conjunctivitis is an isolated finding or an early sign of COVID-19.
Interventions
None listed
Sponsors
Johns Hopkins University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 18 years old or older * Willingness to participate * Presents with red eye complaint
Exclusion criteria
* Adults lacking capacity to consent * Adults with special needs due to physical, medical, developmental or cognitive conditions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of conjunctival samples tested positive for SARS-CoV-2 | 1 year | Number of conjunctival samples with positive PCR divided by the total number of conjunctival samples |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of nasal samples tested positive for SARS-CoV-2 among patients with positive conjunctival samples | 1 year | Number of nasal samples with positive PCR divided by the number of conjunctival samples with positive PCR |
| Proportion of nasopharyngeal samples tested positive for SARS-CoV-2 among patients with positive conjunctival samples | 1 year | Number of nasopharyngeal samples with positive PCR divided by the number of conjunctival samples with positive PCR |
| Rate of development of COVID-19 in the study patient population | 1 year | Number of patients developed COVID-19 divided by the number of the study population |
| Positive conjunctival sample rate in patient developed COVID-19 | 1 year | Number of conjunctival samples with positive PCR divided by the number of patients developed COVID-19 |
Countries
United States
Outcome results
None listed