COVID-19, Critical Illness, Pulmonary Embolism, Pulmonary Embolism and Thrombosis, Sars-CoV2, SARS-CoV Infection, Venous Thromboembolism, Venous Thromboses, Venous Thromboses, Deep, Venous Thrombosis Pulmonary
Conditions
Brief summary
Severe COVID-19 patients at a high risk of venous thromboembolism. We studied patients in 2 intensive care units of university hospitals in Barcelona and Badalona, Spain. We performed a cut-off screening of deep venous thrombosis (DVT) with bilateral duplex ultrasound to 230 patients.
Detailed description
SARS-CoV-2 infection has been associated with coagulation disorders and increased risk of venous thromboembolism (VTE). The aim of the study is to determine the cumulative incidence of VTE in critically ill patients with COVID-19 and its impact on prognosis. Methods Cohort study of critically ill patients due to COVID-19. A bilateral venous compression (CUS) ultrasound screening of the lower extremities was performed during a cut-off period in 2 intensive care units of university hospitals in Spain. Asymptomatic and symptomatic VTE were registered: pulmonary embolism (PE) (diagnosed by CT-angiography) and deep venous thrombosis (DVT). The characteristics of the patients, results of their blood tests and their evolution after 7 days of follow-up were recorded.
Interventions
DIAGNOSTIC_TESTDuplex ultrasound and Computed Tomography Angiography
All venous thromboembolisms suspected will diagnosed with ultrasound and CT-angiography
Sponsors
Hospital Universitari Vall d'Hebron Research Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with severe COVID-19 pneumonia admitted to the intensive care unit
Exclusion criteria
* Treatment with Extracorporeal membrane oxygenation (ECMO) * Pregnant or postpartum women * Under 18 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Venous thromboembolisms | 7 days | Patients with symptomatic pulmonary embolism confirmed on the CT-angiography and those with a swollen limb and confirmed deep venous thrombosis on compression ultrasound were considered to have symptomatic venous thromboembolisms. The remaining patients with positive limb ultrasound or CT-angiography were considered to have asymptomatic venous thrombembolism |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Deaths | 7 days | Deaths from all causes during the follow-up |
Countries
Spain
Outcome results
None listed