Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy

Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy: A Randomized Controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04374188

Enrollment

200

Registered

2020-05-05

Start date

2019-09-01

Completion date

2022-03-01

Last updated

2021-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nephrolithiasis

Brief summary

Efficacy of ciprofloxacin therapy in avoidance of sepsis in patient undergoing percutanous nephrolithotomy. A randomized controlled trial.

Detailed description

To figure out the value of oral ciprofloxacin medication in ameliorate the outcome of renal nephrolithiasis extraction via the endoscope as regard the sepsis.

Interventions

DRUGCiprofloxacin

drug adminstration to ameliorate sepsis incidence

DRUGLevofloxacin

levofloxacin pill

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Caregiver, Outcomes Assessor)

Intervention model description

Efficacy of ciprofloxacin therapy in sepsis avoidance.

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 1\. Patient 18 years or older * Stones ≥ 2 cm and/or mild to moderate hydronephrosis * Sterile mid urine stream

Exclusion criteria

* Patients with a stent, nephrostomy tube or indwelling catheter * Renal failure * Fever before surgery * Previous manipulation/procedure * Concomitant bladder stone or tumour * Patients with active UTI * Contralateral renal/ureteric stone

Design outcomes

Primary

Measure	Time frame	Description
Effect of ciprofloxacin versus levofloxacin duration before PCNL	12 months	To evaluate whether 7 days of ciprofloxacin or levofloxacin before PCNL, can reduce upper urinary tract infection and urosepsis after PCNL.

Secondary

Measure	Time frame	Description
differences between Culture and sensitivity (C&S) of Preoperative urine (MSU) and intraoperative renal pelvic urine	12 months	Compare the difference between C&S of Preoperative urine (MSU) and intraoperative renal pelvic urine and extracted stone, in predicting the upper urinary tract infection and urosepsis.
predictors of systemic inflammatory response syndeome (SIRS) and sepsis post PCNL.	12 months	assess the risk factors for SIRS and sepsis in PCNL.

Countries

Egypt

Contacts

Primary ContactDiaa Eldin Taha, MD

drdiaaeldin@gmail.com01008531384

Backup ContactHossam Nabeeh, MD

dr_hossam_nabeeh@yahoo.com

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026