Neonatal Hyperbilirubinemia, Phototherapy Complication
Conditions
Brief summary
The aim of this study is to investigate the influence of the use of different types of phototherapy on different lymphocytes subsets CD4 and CD8 in the treatment of hyperbilirubinemia in neonates.
Interventions
DEVICEphototherapy
estimate CD4 and CD8 subsets in neonates with unconjugated hyperbilirubinemia after exposure to phototherapy
Sponsors
Rania Ali El-Farrash
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Days to 28 Days
Healthy volunteers
Yes
Inclusion criteria
Term neonates with a gestational week higher than 37weeks, according to the guidelines of the American Academy of Pediatrics (2004) which stated that gestational ages of newborns are determined according to the first day of the mother's last menstrual period (by the mother's statement) and were additionally confirmed by the Ballard scoring system (Ballard et al., 1991) and antenatal ultrasonographic estimation or obstetric records if present. * Clinically significant indirect hyperbilirubinemia requiring phototherapy in the first week of life. * No pathologic etiological factors for hyperbilirubinemia
Exclusion criteria
* Total bilirubin level of \>20 mg/dl. * Prematurity. * Sepsis. * Congenital anomaly. * Elevation in direct bilirubin level. * History of immune deficiency the family. * History of preeclampsia or any other diseases or drug use of the mother
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of types of phototherapy on change in CD4 and CD8 lymphocytes subsets | 2 days | Detection of CD4 and CD8 absolute counts(x10³/uL) : was done before and 48 hours after phototherapy and for controls at time of examination using monoclonal antibodies and measured by flow cytometry |
Countries
Egypt
Outcome results
None listed