Decision Making
Conditions
Brief summary
The goal of this application is to gain a deeper understanding of decision-making for genetic testing and identify effective choice-architecture-based strategies to improve decisions in genetic testing. The investigators hypothesize that choice architecture (i.e. framing) affects decision-making for hypothetical genetic testing scenarios.
Detailed description
After providing opt-in electronic consent, eligible consented participants will be randomized to one of two hypothetical genetic testing scenarios (rare, life-altering genetic condition or common, life-threatening genetic condition). The genetic testing scenarios include brief detailed information about genetic testing (i.e. how results may influence treatment decisions) as well as information about standard approaches to treatment. Subjects will be randomized to receive a framing conditions (e.g. choice, opt-in, opt-out, enhanced choice). Participants will select a preferred testing option to the hypothetical scenario and will complete several validated instruments.
Interventions
BEHAVIORALchoice decision frame
active choice for genetic testing
BEHAVIORALopt-in decision frame
gain frame for genetic testing
BEHAVIORALopt-out decision frame
loss frame for genetic testing
BEHAVIORALenhanced choice (context) decision frame
consequences of genetic testing
BEHAVIORALenhanced choice (norms) decision frame
social norms for genetic testing
BEHAVIORALenhanced choice (affect) decision frame
commitments for genetic testing
Sponsors
Boston College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Subject)
Masking description
participants are blinded to arm and decision frame
Intervention model description
Randomization to 1 of 6 decision frames for two disease testing scenarios (arms)
Eligibility
Sex/Gender
ALL
Age
18 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* Adult participants (18-64 yrs) residing in North America (who are members of the Amazon Mechanical Turk platform)
Exclusion criteria
* age \<18yrs or \>65yrs or residing outside of North America
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genetic testing decision | after reading the scenario and viewing frame (approximately 10 minutes) | Opting yes for genetic testing or no refusing genetic testing |
| Satisfaction with Decision Scale (SWD) | study completion (approximately 30 minutes) | SWD is a validated 6-item instrument, items are scored on a 1-5 scale with higher scores indicating greater satisfaction with the decision taken |
| Decisional Regret Scale (DRS) | study completion (approximately 30 minutes) | DRS is a validated 5-item instrument, items are scored on a 1-5 scale with higher scores indicating more regret with the decision taken |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Newest Vital Sign (NVS) | study completion (approximately 30 minutes) | NVS is a validated 6-item instrument, questions are based on reading and interpreting a food label, higher scores (more correct answers) indicate greater levels of literacy and numeracy abilities |
| Experience with genetic disease | Baseline (study onset) | Single yes/no question to determine a personal or family experience the genetic condition being presented in the scenario (arm) |
Countries
United States
Outcome results
None listed