Bone Morphogenetic Protein-2 In Grade II Furcation Defects.

Recombinant Human Bone Morphogenetic Protein-2 In Absorbable Sponge Vs Platelet Rich Fibrin (PRF) In Grade Ii Furcation Defects - A Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04372420

Enrollment

Registered

2020-05-04

Start date

2017-12-05

Completion date

2019-10-10

Last updated

2020-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Brief summary

The present study evaluated clinically and radiographically the regenerative potential of rhBMP-2 in absorbable sponge and PRF in Grade II furcation.

Detailed description

44 subjects were enrolled in the study. PPD, CAL, plaque index and gingival index were recorded and the evaluation of bone fill was performed after 6 months by using ImageJ® software. After 6 months, the bone fill obtained with rhBMP-2 was higher when compared to PRF. From this trial conducted over a period of 6 months, the unique properties associated with rhBMP-2 in absorbable sponge makes it a potential agent to be used as a graft material for Grade II furcation defects.

Interventions

DRUGRhBMP-2 absorbable sponge in grade II furcation

The collagen sponge is impregnated with rhBMP-2 at a concentration of 0.5 μg/ml/1cm3 and were stored at 4°C. This rhBMP-2 impregnated collagen sponge was then dispensed at grade II furcation site

PROCEDUREPLATELET RICH FIBRIN in grade II furcation

For preparation of PRF, patient's venous blood is collected into 10ml glass tube or glass-coated plastic tube and centrifuged at 2700 rpm for 12min which leads to two different layers in the test tube, the upper platelet rich fibrin and the lower RBC portion. The formed PRF clot could then be removed from the glass tube and used in grade II furcation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Masking description

participant and outcome assessor are masked from the study

Intervention model description

Group A- RhBMP-2 absorbable sponge is placed in grade II furcation and Group B- PRF is placed in the grade II furcation

Eligibility

Sex/Gender

ALL

Age

20 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Systemically healthy male and female patients of age group 20-55 yrs * grade II furcation involvement and probing pocket depth of ≥5mm

Exclusion criteria

* Medically compromised patients * subjects who underwent radiotherapy or chemotherapy in the past 12 months * patients having uncontrolled periodontal disease and * subjects smoking ≥10 cigarettes per day were excluded

Design outcomes

Primary

Measure	Time frame	Description
BONE FILL	6 MONTHS	The evaluation of bone fill was performed after 6 months by using ImageJ® software.

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026