Endometrioma, Inflammation
Conditions
Keywords
endometrioma, adropin, salusin-α, netrin-1, nesfatin-1, insulin resistance
Brief summary
Investigators aimed to measure the serum levels of adropin, salusin-α, netrin-1, and nesfatin-1, anti-inflammatory effects of which have been demonstrated previously, in endometriosis patients and to find out any association of them with insulin resistance.
Detailed description
Endometriosis is defined as the presence of endometrial gland and stroma outside the endometrial cavity affecting almost 10% of the women of reproductive age. Although benign, it disrupts the quality of life of the inflicted patients through symptoms such as dysmenorrhae, dyspareunia, chronic pelvic pain, and infertility. The pathogenesis of endometriosis has not yet been clearly elucidated, however, recent papers implies an underpinning role of inflammation There is a limited number of studies about the levels of these parameters in endometriosis and to date, no report is available on the levels of adropin and netrin-1 in endometriosis. Likewise, according to the investigator's literature search, no research explaining the association of endometriosis with insulin resistance has yet been published. In present study, in an attempt to describe inflammatory pathways playing a role in endometriosis pathogenesis, Investigators aimed to measure the levels of serum adropin, salusin-α, netrin-1, and nesfatin-1, anti-inflammatory effects of which have been priorly demonstrated, and to find out any association of them with insulin resistance.
Interventions
DIAGNOSTIC_TESTAdropin (ng/L)
Thawed samples were measured on a Molecular Devices SpectraMax i3 Multi-Mode, Microplate Reader (batch number: SER 35 370-1448, made in Austria) using enzyme linked immunosorbent assay (ELISA).
Sponsors
Muğla Sıtkı Koçman University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
·Histopathologically confirmed diagnosis of endometrioma
Exclusion criteria
* Any patients with DM, * chronic kidney disease (CKD), * CAD, * heart failure (HF), * cerebrovascular accident (CVA), * malignancy, * rheumatoid disorder, * liver disease, and * active infections were excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum Adropin level | preoperative in the morning or Day 1 in outpatient clinic,preprandial for healthy volunteers | Serum Adropin level in ng/L |
| Salusin-α | preoperative in the morning or Day 1 in outpatient clinic, preprandial for healthy volunteers | Serum Salusin-α level in pg/mL |
| Netrin-1 | preoperative in the morning or Day 1 in outpatient clinic, preprandial for healthy volunteers | Serum Netrin-1 level in pg/mL |
| Nesfatin-1 | preoperative in the morning or Day 1 in outpatient clinic, preprandial for healthy volunteers | Serum Nesfatin-1 level in ng/L |
Countries
Turkey (Türkiye)
Outcome results
None listed