Cholangitis, Secondary Biliary, Treatment Compliance, Antibodies Drug Specific
Conditions
Keywords
Cholangitis, biliary atresia, kasai Portoenterostomy, antibiotics, treatment
Brief summary
Application of multi-center, prospective study on the severity of postoperative cholangitis biliary atresia classification, according to the degree of cholangitis targeted therapy, to improve the therapeutic effect of postoperative cholangitis biliary atresia, decrease the overuse of antibiotics related complications.
Detailed description
Cholangitis patients post-kasai Portoenterostomy were grouped by cholangitis severity score, according to the severity was divided into mild, moderate, severe cholangitis, all levels of cholangitis patients were divided into subgroups by age and post-kasai Portoenterostomy jaundice matching design of experiment, then they were randomly divided into control group and experimental group, and all the control group unified antibiotic treatment, the experimental group was graded antibiotic treatment according to the severity cholangitis, after three days treatment，evaluate each treatment effect, average hospitalization days, the average hospitalization expenses, antimicrobial drug use strength to evaluate the therapeutic effect of postoperative cholangitis biliary atresia.
Interventions
DRUGSulperazon
moderate cholangitis patients were treated with these drugs for 7days,unless the patients were cured or must be changed the therapeutic.
DRUGTeicoplanin
severe cholangitis patients were treated with these drugs for 7days,unless the patients were cured or must be changed the therapeutic.
cholangitis in control group were treated with these drugs for 7days,unless the patients were cured or must be changed the therapeutic.
Sponsors
Shanghai Children's Hospital
Tongji Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Cholangitis patients post-kasai Portoenterostomy were grouped by cholangitis severity score, according to the severity was divided into mild, moderate, severe cholangitis, all levels of cholangitis patients were divided into subgroups by age and post-kasai Portoenterostomy jaundice matching design of experiment, then they were randomly divided into control group and experimental group.
Eligibility
Sex/Gender
ALL
Age
3 Months to 2 Years
Healthy volunteers
No
Inclusion criteria
1. Age 3 months to 2 years old, gender is not limited. 2. Patients with cholangitis post-kasai Portoenterostomy. 3. No other treatment before entering the group. 4. The patient must sign an informed consent form and can actively cooperate with the treatment and follow-up.
Exclusion criteria
1. Patients with other infectious lesions. 2. Patients with other severe deformity. 3. Patients with end-stage liver failure. 4. Patientsn with liver transplantation. 5. Patients with mental symptoms or other disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recovery rate | 7 days | The cure indicator including:1.Temperature:T≤37.5℃; 2. Infection index:WBC\<10x109/L, CRP\<10mg/L. After 7days treatment, we calculate the cure number and recovery rate of each group to evaluate the efficiency. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Recurrence rate | 1 year | To collect recurrent episode of cholangitis and recurrent rate of each group. |
Countries
China
Outcome results
None listed