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Silver Diamine Fluoride Treatment of Active Root Caries Lesions in Older Adults: A Case Series

Silver Diamine Fluoride Treatment of Active Root Caries Lesions in Older Adults: A Case Series

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04370080
Enrollment
63
Registered
2020-04-30
Start date
2017-01-03
Completion date
2019-11-21
Last updated
2020-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Root Caries

Brief summary

The authors conducted a case series to determine the outcomes of treatment of root surface caries lesions when the teeth were treated topically with 38% silver diamine fluoride.

Detailed description

The study is a prospective, single center case series. The cases were consecutive. Participation was offered to every patient who qualified based on age and the presence of an active lesion in a root surfaces, in a furcation, or under an individual crown or crown abutment for a fixed prosthesis. The study was conducted at the dental clinic of the Roseman College of Dental Medicine in South Jordan, Utah. The University of California, San Francisco protocol for applying topical silver diamine fluoride was adapted for use with these patients. Lesions were flushed with water and then dried with compressed air, isolated with cotton rolls, and then 38% silver diamine fluoride (Advantage Arrest, Elevate Oral Care, West Palm Beach, FL) was applied repeatedly for two minutes with the manufacturer supplied dental applicator. The silver diamine fluoride was stored under the manufacturer's recommended conditions. If the patient complained about the taste, the lesion was coated with sodium fluoride varnish. All of the lesions were reevaluated for dental caries lesion activity about every six months and retreated regardless of their arrest status. Follow-up was for 30 months or until loss to follow-up.

Interventions

Dental caries arrest medication

Sponsors

Roseman University of Health Sciences
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

Case series, consecutive

Eligibility

Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* At least 1 active root surface caries lesion by Nyvad criteria

Exclusion criteria

* None

Design outcomes

Primary

MeasureTime frameDescription
Dental caries lesion activity 524-30 monthsNyvad score based on visual/tactile examination
Dental caries lesion activity 16-12 monthsNyvad score based on visual/tactile examination
Dental caries lesion activity 2<6 monthsNyvad score based on visual/tactile examination
Dental caries lesion activity 312-18 monthsNyvad score based on visual/tactile examination
Dental caries lesion activity 418-24 monthsNyvad score based on visual/tactile examination

Secondary

MeasureTime frameDescription
Caries lesion fluorescence 1<6 monthsLaser fluorescence measurement at the surface of the lesion
Caries lesion fluorescence 26-12 monthsLaser fluorescence measurement at the surface of the lesion
Caries lesion fluorescence 312-18 monthsLaser fluorescence measurement at the surface of the lesion
Caries lesion fluorescence 418-24 monthsLaser fluorescence measurement at the surface of the lesion
Caries lesion fluorescence 524-30 monthsLaser fluorescence measurement at the surface of the lesion

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026