7 TESLA, BRAIN, MRI, PTX
Conditions
Keywords
MRI, PTX, BRAIN, 7 TESLA
Brief summary
Magnetic resonance imaging (MRI) is a non-invasive imaging modality used in routine clinical practice for clinical diagnosis by visualizing the anatomical structure and in vivo function of certain organs. The development of ultra-high field MRI systems with 7.0-T or higher, gives access to a new field of exploration of the human body by improving the speed of acquisition but also a better signal-to-noise ratio (SNR) and better resolution. In order to fully exploit the potential of these ultra-high field MRI scanners, various technical issues must be adressed. Indeed, the non-uniformity of the transmission field is one of them leading to non-uniform images with spatially varying contrast. Thus the pTX (parallel transmission) mode using multiple transmission channels allows spatial and temporal control over the RF waves.
Interventions
OTHERMRI
A MRI in PTX mode will be done on healthy subject (approx. 90 min of sequences)
Sponsors
Poitiers University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age ≥ 18 years old * Subject with no MRI contraindications (metallic shine, pacemaker) * Free subject, without guardianship or curatorship or subordination * A person affiliated to or beneficiary of a social security scheme. * Informed and signed consent by the healthy volunteer after clear and fair information about the study
Exclusion criteria
* Subject with a contraindication to MRI (pregnancy, ocular metallic foreign body (accidental or other shrapnel); pacemaker (cardiac stimulator), implantable defibrillator, non MRI 7.0 T compatible neurostimulator, cochlear implants and generally any irremovably implanted electronic medical device; metallic heart valve, vascular clips formerly implanted on cranial aneurysm), metallic prostheses. * Healthy volunteers suffering from claustrophobia * Persons not benefiting from a Social Security scheme or not benefiting from it through a third party. * Persons benefiting from reinforced protection, i.e. minors, pregnant and breastfeeding women, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection and finally, patients in emergency situations. * Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: per os, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the improvement of the Signal to Noise Ratio (SNR) in parallel transmission mode (pTx) versus without pTx at 7.0 T on different cerebral anatomical regions/structures (central gray nuclei, cerebellum, white matter, cortex). | 1 year | The main evaluation criterion is the value of the signal-to-noise ratio in a global way but also by a unit comparison approach (voxel to voxel). It will be a question of linking these variations to the flip angles but also to the probable inhomogeneities of the B1+ field. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the body temperature | 1 year | Measurement of body temperature in healthy volunteers using a forehead thermometer before and after examination |
| Evaluation of anxiety before, during and after the MRI | 1 year | Measurement of the healthy subject's feelings about the exam (anxiety, heat, nausea) using a grid proposed at the end of the exam. |
Countries
France
Contacts
Primary ContactRémy GUILLEVIN, Pr
Outcome results
None listed