Acute Respiratory Distress Syndrome
Conditions
Keywords
ventilation, artificial, respiratory distress syndrome, adult, prone position, monitoring, physiologic
Brief summary
The primary objective of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning while mantaining the same ventilatory setting. The secondary objetive of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning and adjusting an individualized ventilatory setting.
Detailed description
Data of mechanical power will be collected prospectively in three different times: 1. In supine positioning (T0). 2. After 15 minutes of having implemented prone positioning while maintaining the same ventilatory settings that in supine (T1). 3. In prone positioning after 15 min of having adjusted an individualized ventilatory setting (T2). Besides, the investigators will take an arterial blood sample in T0 and T2 to calculate changes in oxygenation status and ventilatory ratio. In case that esophageal manometry is available, the investigators will collect data regarding to transpulmonary and esophageal pressure in order to calculate the mechanical power applied to the lung parenchyma.
Interventions
OTHERProne position
The patients will be put in prone position while receiving invasive mechanical ventilation and the investigators will monitor changes in mechanical power applied to the respiratory system and compare with supine position
Sponsors
Sanatorio Anchorena San Martin
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged older than 18 years old under invasive mechanical ventilation with diagnostic criteria of acute respiratory distress syndrome acording to berlin definition and neccesity of prone positioning.
Exclusion criteria
* Need to interrump prone positioning maneuver. * Inability to collect data for any reason.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mechanical power of the respiratory system measured in supine compared with prone position while maintaining the same ventilatory setting | 1) Supine position; 2) Prone position, after 15 min | Mechanical power measured in Joules/min |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mechanical power of the respiratory system measured in supine compared with prone position after adjusting the ventilatory setting | 1) Supine position; 2) Prone position, after 15 min of adjusting ventilatory setting. | Mechanical power measured in Joules/min |
Countries
Argentina
Outcome results
None listed