Cardiovascular Diseases
Conditions
Brief summary
A multi-site, multi-modality prospective observational clinical outcomes study focussed on the development of phenotype-dirven risk prediction modelling in patients with known or suspected cardiovascular disease.
Detailed description
The Cardiovascular Imaging Registry of Canada (CIROC) was conceived to provide a common standardized architecture for the collection of clinically reported imaging biomarkers, demographic information, resource utilization and clinical outcomes among patients referred to non-invasive cardiac imaging. The Registry was designed to assess the feasibility of implementing personalized care strategies through automated high quality data collection and patient engagement. The CIROC Registry was launched with inaugural focus on Cardiac MRI base phenotyping, however has evolved to encompass cardiac CTA and echocardiography. Clinically referred patients are engaged by automated, tablet-based tools to collect informed consent and deploy standardized patient health assessments. Standardized reporting of disease features are captured using bespoke reporting tools. All patients are prospectively followed for a period of 10-years using linkage to administrative health data, inclusive of ICD-coded events, laboratory test results, ECG and vital statistics.
Interventions
DIAGNOSTIC_TESTDiagnostic testing performed as per routine care
Sponsors
Alberta Health services
University of Calgary
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients referred for hospital-based cardiac imaging services
Exclusion criteria
* Failure or provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Major adverse cardiovascular outcomes (MACE) | 2024 | Composite of all-cause death, heart failure admission, myocardial infarction, heart transplantation or LVAD, Stroke or TIA |
| Malignant arrhythmic events | 2024 | Composite of sudden cardiac death or appropriate ICD shock |
| Heart failure events | 2024 | Composite of heart failure admission, death or need for transplantation / LVAD |
| Atrial arrhythmic events | 2024 | Occurrence of atrial fibrillation / atrial flutter (documented by 12-lead ECG or Holter monitor) |
| All-cause mortality | 2024 | Death based on Vital Statistics Alberta and In-hospital coded death |
Countries
Canada
Contacts
Primary ContactJames White
Backup ContactSandra Rivest
Outcome results
None listed