Brain Tumor, Primary
Conditions
Keywords
Parenchymal brain tumors, Intraaxial brain tumors, Gliomas, Glioblastoma multiforme, Low grade glioma, High grade glioma, Intraoperative Ultrasound (IOUS), Tumor Surfacing, Tumor expansion, Contrast enhanced magnetic resonance imaging (CEMRI) brain, Contrast enhanced computed tomography (CECT) brain
Brief summary
We planned to evaluate the change in tumor dimensions of intraaxial parenchymal tumors after craniotomy by comparing the tumor size on intraoperative ultrasonography (IOUSG) with pre-operative CECT and CEMRI brain.
Detailed description
Background: No previous study to determine the intraoperative changes in the tumor dimensions had been undertaken previously. Objectives: We planned to evaluate the change in tumor dimensions of intraaxial parenchymal tumors after craniotomy by comparing the tumor size on intraoperative ultrasonography (IOUSG) with pre-operative CECT and CEMRI brain. Study Design: This was a prospective observational study. Participants: Patients aged 15-65 years undergoing surgery at SKIMS for intraaxial parenchymal intracranial tumors were included. Methods: Standard pre-operative CECT and CEMRI brain were done to measure tumor dimensions and compared with IOUSG.
Interventions
None listed
Sponsors
Sheri Kashmir Institute of Medical Sciences
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* All patients above the age of 15 years conferring to Grade I and II of American Society of Anesthesiologist (ASA) physical status classification system, undergoing elective craniotomy with intracranial tumor excision were included in this study. Patients with or without any neuro-deficit were also included. Only those patients in whom all the tumor dimensions could be defined with precision on pre-operative CECT, CEMRI and IOUSG were included in the final analysis.
Exclusion criteria
* Patients' in whom there are multiple intracranial tumors (e.g. metastasis), deep seated tumors, inability to use IOUSG and in whom exact tumor dimensions cannot be defined either on pre-operative CECT/CEMRI or on IOUSG were excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tumor dimension change | March 2018 to November 2019 | Change in tumor dimension, surface area and volume when comparing intraoperative ultrasound with pre-operative CEMRI and CECT brain |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tumor distance from dural surface | March 2018 to November 2019 | Change in the distance of tumor from dural surface as measured on intraoperative ultrasound when comparing it with pre-operative CEMRI and CECT brain |
| Relationship of tumor size change with other characteristics | March 2018 to November 2019 | Relationship of tumor size change with tumor consistency, tumor characteristics, histopathology, tumor location |
Countries
India
Outcome results
None listed