SARS-CoV-2 Associated Respiratory Failure Recovery (COVID-19 CAir)

Recovery in Patients With SARS-CoV-2 Associated Respiratory Failure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04365595

Enrollment

Registered

2020-04-28

Start date

2020-06-03

Completion date

2021-02-17

Last updated

2021-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID, SARS-CoV 2

Brief summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the current pandemic of coronavirus disease (COVID-19) that can lead to respiratory failure requiring oxygen therapy. Some patients develop acute respiratory distress syndrome (ARDS) and may die despite intensive care therapy. Currently it is unknown a) how fast patients recover after being discharged from hospital and b) what underlying predictors may influence recovery.

Detailed description

Study aims: * To evaluate subjective and objective recovery after discharge from hospital in patients with respiratory failure due to COVID-19. * To identify risk factors for COVID-19 associated respiratory failure and prolonged recovery

Interventions

OTHERQuestionnaires, spirometry

Questionnaires targeting health-related quality-of-life, symptoms, anxiety and depression

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* hospitalization at University Hospital Zurich due to COVID-19 infection * hospital discharge max. 4 weeks ago * requiring supplemental oxygen

Exclusion criteria

* \<18 years * non-German speaking * no smartphone access

Design outcomes

Primary

Measure	Time frame	Description
Health-related quality-of-life	3 months	European Quality of Life - 5 Dimensions - 5 Levels Instrument (EQ-5D-5L). Scoring: Index ranges from 1 to \<0, with lower scores indicating more limitations.

Secondary

Measure	Time frame	Description
Spirometry	1 month	Forced expiratory volume in one second (FEV1) in liters and percent predicted.
Symptom burden	3 months	COPD Assessment Test (CAT). Scoring: Scores range from 0-40, with higher scores indicating more symptoms due to respiratory limitations.
Anxiety and depression	3 months	Hospital Axiety and Depression Score (HADS). Scoring: Scores range from 0 to 42, with higher scores indicating more anxiety or depression symptoms.

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026