Contraceptive Usage, Diffuse Noxious Inhibitory Control
Conditions
Brief summary
The purpose of this study is tu assess the influence of oral contraceptives (OC) on diffuse noxious inhibitory control (DNIC) in healthy women, tested during high, low endogenous estrogens sessions and ovulatory period.
Detailed description
After being informed about the study and it protocol, all patients giving written informed consent, will undergo to a cephalic (masseter) and extracephalic (finger) mechanical stimulus to evaluate the threshold of mechanical pain, and physiological records of systolic/diastolic pressure and heart rates. After, we will evaluate the threshold response and physiological rates to the same mechanical stimulus under a thermal (cold) conditional pain (TCP) at 3 different moments of menstrual period in No contraceptive group (No OC) versus Contraceptive group (CO). Finally, we will compare the mechanical threshold response, physiological rates and pain perception between both groups.
Interventions
DEVICEMechanical stimulus
Electrical dynamometer to measure mechanical pressure
PROCEDUREThermal (cold) stimulus
Water cold bath
Oral contraceptive (OC)
OTHERNo oral contraceptive (No OC)
No oral contraceptive (No OC)
Sponsors
Universidad Vina del Mar
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
15 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy women with oral contraceptive treatment (for at least 3 consecutive months), greater than or equal to 15 years old. * Healthy women without oral contraceptive treatment, greater than or equal to 15 years old. * Non pregnant women. * Not under convulsive, chronic pain, antidepresive, antihypertensive, pharmacological treatments * Without systemic pathologies.
Exclusion criteria
* Treatment of a pain, depression, hypertension, convulsion condition with or without medication. * Regular use of benzodiazepines. * Systemic pathologies * Pregnant women * Menopausal women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diffuse Noxious Inhibitory Control Efficiency in oral contraceptive healthy women | Baseline phase 1 (2-5 days), phase 2 (14-17 days), and phase 3 (21-27 days) after the beginning of menstrual period | The efficiency of diffuse noxious inhibitory control (DNIC) is a measure of one's ability to inhibit pain perception. DNIC efficiency is assessed by a psychophysical test that involves a mechanical pressure in the masseter (cephalic) and finger (extracephalic) stimulus as the test stimulus and a cold-water bath as the conditioning stimulus. The results of this test will be used as the primary outcome measure. |
Countries
Chile
Outcome results
None listed