Chronic Fatigue Syndrome, Intensive Care Unit, Muscle
Conditions
Keywords
Neuromuscular function, Fatigability
Brief summary
Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This symptom seems particularly pronounced in Covid-19 patients and may affect their quality of life by decreasing their capacity to perform simple tasks of daily life. The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in the feeling of fatigue of Covid-19 patients. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology and its recovery will allow to optimize rehabilitation treatments to shorten the persistence of chronic fatigue and in fine improve life quality.
Interventions
OTHERQuestionnaires
Quality of life Depression Physical pain Social provisions Quality of sleep
BIOLOGICALblood test
complete blood count and cytokine concentration, TNF-alpha, LDL oxidized, AOPP, SOD, GPX, catalase, albumin, transthyretin, RBP, transferin, α-1 glycoprotein acide, ferritine, selenium, zinc, magnesium
OTHERMaximal effort test
The maximal effort test with VO2max recordings will be assessed during the first visit to the laboratory.
DEVICEactigraphy
assessment of sleep quality
DEVICENeuromuscular evaluation
* The maximum isometric force produced by the knee extensors will be measured on the ergometer * the intensity of muscular electrical activity recorded by surface electromyography * Peripheral nerve stimulation * Transcranial magnetic stimulation * Magnetic resonance imaging
OTHERstool analysis
analyze the composition of the intestinal microbiote. concerns only the patients of Saint Etienne
OTHERfood diary
3 days of information to determine nutrient intakes. concerns only the patients of Saint Etienne
Sponsors
University of Saint-Etienne
Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
for patients who have been in intensive care : * Diagnosed with Covid-19 * Ventilated in ICU for at least 3 consecutive days * ICU discharge between 4 and 8 weeks * Approval received from a physician * Command of the French language Inclusion Criteria for patients who have NOT been in intensive care : * Diagnosed with Covid-19 : positive serological test or positive PCR test following nasopharyngeal swabbing * Approval received from a physician * Command of the French language
Exclusion criteria
* Taking neuroactive substances that can alter corticospinal excitability * Patients with co-morbidities leading to significant fatigue: e.g. cancerous pathologies, sleep apnea * Patients with neurodegenerative or neuromuscular disease * Contraindication to the application of a magnetic field * Contraindication to the practice of Magnetic Resonance Imaging * Participant is pregnant * Patients with psychiatric disorders * Paraplegic and hemiplegic patients * Addictive disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| voluntary maximum force reduction | 6 weeks post-discharge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neuromuscular function : Peripheral function | 6 weeks post-discharge | Peripheral function by electrical nerve stimulation |
| Maximal oxygen uptake (VO2max) | 6 weeks post-discharge | measured by effort test |
| quality of sleep | 6 weeks post-discharge | measured by actigraphy |
| Neuromuscular function : cortical activity | 6 weeks post-discharge | Level of cortical activation and cortico-spinal excitability measured by transcranial magnetic stimulation |
| metabolic fatigue | 6 weeks post-discharge | measured by a Phosphorus 31 Nuclear magnetic resonance test |
| microbiote intestinal | baseline and 6 months | stool analysis (concerns only the patients of Saint Etienne) |
| muscle volume | 6 weeks post-discharge | with Magnetic resonance imaging |
Countries
France
Outcome results
None listed