COVID, Obstructive Sleep Apnea, Pneumonia
Conditions
Keywords
COVID, Obstructive Sleep Apnea, Pneumonia
Brief summary
Covid-19 infection is an on-going pandemic with worse diagnosis in adults with comorbid conditions such as hypertension and cardiopulmonary diseases. Obstructive sleep apnea (OSA) is common in those comorbidities and may contribute to worse prognosis for the Covid-19 cases.
Detailed description
The investigators' primary aim is to address the association between the high probability of having OSA and Covid-19 outcomes within 28 days of the hospitalization. Secondary outcomes will be conducting a polysomnography in cases with high probability of having OSA compared to those with low probability, approx. 4 months after the Covid-19 diagnosis, and re-evaluate the association of the verified OSA diagnosis and severity with the outcomes in the first 4 weeks as well as with the outcomes after 4 months.
Interventions
DIAGNOSTIC_TESTHome Sleep Apnea Testing or In-hospital Polysomnography
Home Sleep Apnea Testing or In-hospital Polysomnography will be conducted 4 to 6 months after the Covid-19 diagnosis
Sponsors
Koc Healthcare Istanbul American Hospital, Marmara University Hospital
Koç University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients with Covid 19 diagnosis * Ability to read and speak * Signed informed consent.
Exclusion criteria
* Subjects with limited life expectancy due to advanced renal disease or uncontrolled malignancies * Subjects with alcohol dependency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The rate of clinical improvement | 7 days | Defined as a decline of 2 categories from admission on a 7-category ordinal scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical status - improvement | 7, 14, 21, 28 days | Time to hospital discharge, ICU discharge, weaning from intubation, weaning from supplemental oxygen, incident pneumonia, ARDS, in-hospital mortality |
| Clinical status - worsening | 7, 14, 21, 28 days | Defined as an increase in category on a 7-category ordinal scale from admission |
Other
| Measure | Time frame | Description |
|---|---|---|
| Long-term outcomes | 4-6 months after the initial hospital admission | Re-analysis of the correlation of obstructive sleep apnea (objectively verified) severity in terms of apnea-hypopnea index and oxygenation levels with the primary and secondary outcomes as described above (the rate of clinical improvement defined as a decline of 2 categories from admission on a 7-category ordinal scale; time to hospital discharge, ICU discharge, weaning from intubation, weaning from supplemental oxygen, incident pneumonia, ARDS, in-hospital mortality as well as with the lung function, CO-diffusion capacity, cardiac function, CT thorax pathologies, biomarkers (cytokines, polymorphisms) and IgG-antibodies after 4 months. |
Countries
Turkey (Türkiye)
Outcome results
None listed