Traumatic Brain Injury
Conditions
Keywords
traumatic brain injury, magnetic resonance elastography, brain compliance
Brief summary
Traumatic brain injury (TBI) is a major public health issue, and intracranial hypertension in the acute phase remains a critical scientific issue. Many patients with acute closed TBI received conservative, non-surgical treatments at first, while 5%\ 19% of which develops intractable intracranial hypertension that requires emergent surgery. Therefore, it is of great clinical significance to identify patients who are at high risk of deterioration in the early stage. Previous studies have found that brain compliance is a contributive factor to intracranial pressure, and might serve in the development of intracranial hypertension after TBI. We made assumption that intracranial pressure has a negative relationship with brain compliance providing that the volume of hematoma remains constant. However, few studies have applied magnetic resonance elastography (MRE) in evaluating brain compliance in patients with TBI. Therefore, this study is designed to enroll patients with acute closed traumatic brain injury who are initially treated non-surgically. Magnetic resonance elastography (MRE) sequences are performed to non-invasively assess patients' brain compliances, in the hope of exploring the potential value of MRE biomarkers to predict the short-term outcome in patients with acute closed TBI who are initially receive non-surgical treatments.
Interventions
DIAGNOSTIC_TESTMagnetic resonance elastography
All patients enrolled will receive magnetic resonance elastography of the brain.
Sponsors
Xiangya Hospital of Central South University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-60 years old * Acute closed traumatic brain injury within 7 days * Not receiving surgical intervention according to the judgement of neurosurgeons * Expected tolerance of magnetic resonance imaging (MRI) scan 7 days from injury
Exclusion criteria
* Vital organ failure: congestive heart failure, respiratory failure, renal failure (CKD≥stage 3), severe hepatic dysfunction (Child-Pugh stage B or C) * Any central nervous system (CNS) pathology prior to injury: stroke, epilepsy, CNS tumour/infections, dementia or other neurodegenerative diseases * CT reveals infratentorial hematoma * Contraindications of MRI * Currently enrolled in other researches
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 14-day ΔGCS | 14 days after injury | Change of Glasgow Coma Scale (GCS) 14 days after injury from GCS at admission. The GCS is a indication of patient's conscious status, ranging from 3 (poor) to 15 (good). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 14-day mortality | 14 days after injury | All-cause mortality within 14 days from injury. |
| 14-day emergent surgery | 14 days after injury | Emergent surgery due to intracranial pathology within 14 days from injury. The decision of emergent surgery (evacuation of newly emerged hematoma, decompressive craniectomy due to refractory intracranial hypertension, etc) is determined by attending neurosurgeon. |
Contacts
Primary ContactZiyuan Liu, M.D.
Outcome results
None listed