Benign Neoplasm, Head and Neck Cancer, Malignant Neoplasm
Conditions
Brief summary
Study aim was to investigate the diagnostic role of Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) in head and neck cancer.
Detailed description
This study was assessed the role of Diffusion weighted imaging (DWI) in discriminating between benign and malignant lesions in Head and neck cancer as well as studying the relationship between glucose metabolism (18F-FDG) and Apparent diffusion coefficient (ADC) for better tumor assessment.
Interventions
RADIATIONRadiotherapy
Patients have received radiotherapy as a treatment modality for Head and neck cancer
Sponsors
University of Pecs
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
41 Years to 88 Years
Healthy volunteers
Yes
Inclusion criteria
* Proved Head and neck cancer * Underwent PET/CT and PET/MRI * Lymph nodes due to primary Head and neck cancer. For healthy subject: * No previous history of malignancy. * no inflammation or infection in the neck region. * lymph node size \<10mm.
Exclusion criteria
* patients treated before by radiotherapy / chemoradiotherapy * patients underwent surgery * artifacts
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in Apparent diffusion coefficient value between benign and malignant lesions | Baseline | Apparent diffusion coefficient (ADC) was measured from benign and malignant lymph nodes by drawing region of interest (ROI) on the most homogeneous and most solid part in the target lymph node. Higher ADC value in Benign lymph node means that there are more water molecules movement inside the lymph node, more water molecules movement resulting in higher Apparent diffusion coefficient value. in malignant nodes and due to more tumor tissue, the result is to have lower water molecules motion so, lower ADC value. |
Outcome results
None listed