Post Operative Pain
Conditions
Brief summary
This study is investigating whether administration of acetaminophen the day before surgery improves post operative pain following minimally invasive hysterectomy. Patients will receive either acetaminophen or placebo to take twice per day the day prior to their scheduled surgery. The morning of surgery all participants will receive oral acetaminophen at least 30 minutes prior to surgery. The investigators will examine whether there is a difference in post operative pain between the two groups.
Interventions
DRUGAcetaminophen
Preemptive acetaminophen the day before surgery
DRUGPlacebo
Preemptive placebo the day before surgery
Sponsors
Montefiore Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Undergoing minimally invasive hysterectomy for benign indications
Exclusion criteria
* acetaminophen allergy * liver disease * kidney disease * consume \>3 alcoholic beverages per day * weigh \<50 kilograms * report daily opiate use * contraindication to acetaminophen * used acetaminophen within 24 hours of surgery * undergoing a concomitant pelvic reconstructive procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-operative opioid use | 4 hours | The total amount of opiate consumption in the immediate postoperative period will be recorded. Per standard protocol, patient's will be ordered for pain medication to receive on an as needed basis. The amount of both oral and IV opioids consumed by the patient will be converted to total morphine equivalents. As such, post operative opioid use will be used as a proxy for degree of post operative pain. |
Countries
United States
Outcome results
None listed