Hypersensitivity Reactions, Iron-deficiency
Conditions
Keywords
complement activation-related pseudoallergy (CARPA), Hypersensitivity reactions (HSR), iron-deficiency, non dextran iron preparations (NDIPs), anemia
Brief summary
This study aims to evaluate characteristics of patients with previous hypersensitivity reaction grades I-IV to intravenous ferric carboxymaltose (Ferinject) or to iron sucrose (Venofer) including age, atopy status, previous allergic reactions, previous medical history, current medications and co-morbidities. Furthermore, symptoms on reaction such as severity grade of reaction will be evaluated.
Interventions
Data collection (history, clinical presentation, medication, complications, laboratory testing) will be performed from patient records stored in the protected electronic patient system ISMed (Integrated System for Medical Diagnostic) of patients with HSRs to NDIPs.
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participants from 16 years of age and older with previous hypersensitivity reaction grades I-IV to intravenous ferric carboxymaltose (Ferinject) or to iron sucrose (Venofer).
Exclusion criteria
* No previous hypersensitivity reaction to iron preparations or reactions to oral iron preparations. * If a rejection to use patient data is documented in patient records, the patient will be excluded from analysis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| previous medical history | Baseline; Patients with HSRs to NDIPs that were treated at the University Hospital Basel between the 16th of January 2018 and the 24th of October 2019 | Data collection (medical history) will be performed from patient records stored in the protected electronic patient system ISMed (Integrated System for Medical Diagnostic) of patients with HSRs to NDIPs |
| Family history | Baseline; Patients with HSRs to NDIPs that were treated at the University Hospital Basel between the 16th of January 2018 and the 24th of October 2019 | Data collection (Family history) will be performed from patient records stored in the protected electronic patient system ISMed (Integrated System for Medical Diagnostic) of patients with HSRs to NDIPs |
| assessment of hypersensitivity reactions | Baseline; Patients with HSRs to NDIPs that were treated at the University Hospital Basel between the 16th of January 2018 and the 24th of October 2019 | assessment of hypersensitivity reactions (grade I-IV) to Ferinject or Venofer |
| preparation used | Baseline; Patients with HSRs to NDIPs that were treated at the University Hospital Basel between the 16th of January 2018 and the 24th of October 2019 | which preparation was used for Treatment ( iron sucrose (Venofer) or ferric carboxymaltose (Ferinject) |
| co-medication | Baseline; Patients with HSRs to NDIPs that were treated at the University Hospital Basel between the 16th of January 2018 and the 24th of October 2019 | which co-medication was used |
Countries
Switzerland
Outcome results
None listed